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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

Fig. 1

Ambulatory blood pressure was monitored periodically utilizing radio-telemetric transmitters. Mean arterial pressure (MAP) was recorded prior to the beginning of treatment and after 3, 5, 7 and 9 weeks of treatment during the a light and b dark cycles. Compared to ZLC, MAP increased throughout the course of treatment in ZOC. After 9 weeks of treatment MAP was significantly reduced in ZOSV during the light and dark periods compared to ZOC (p < 0.05 indicated by the dagger symbol). n = 4, 4, 4, 3 and 4 for ZLC, ZOC, ZOSV, ZOV and ZOH, respectively

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Cardiovascular Diabetology

ISSN: 1475-2840