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Table 3 Results of multivariate regression analysis

From: How does empagliflozin improve arterial stiffness in patients with type 2 diabetes mellitus? Sub analysis of a clinical trial

Dependent variable: Δ forward wave amplitude Dependent variable: Δ reflected wave amplitude
Model 1 Beta p-value Model 2 Beta p-value Model 1 Beta p-value Model 2 Beta p-value
Sex 0.025 0.873 Sex 0.077 0.612 Sex 0.237 0.108 Sex 0.292 0.040
Age − 0.180 0.243 Age − 0.210 0.162 Age − 0.194 0.169 Age − 0.225 0.104
Δ HbA1c 0.009 0.960 Δ Fasting plasma glucose − 0.155 0.366 Δ HbA1c 0.086 0.599 Δ Fasting plasma glucose − 0.125 0.423
Δ Copeptin 0.095 0.528 Δ Copeptin 0.101 0.492 Δ Copeptin 0.008 0.955 Δ Copeptin 0.025 0.851
Δ Hematocrit − 0.343 0.054 Δ Hematocrit − 0.371 0.037 Δ Hematocrit − 0.142 0.374 Δ Hematocrit − 0.174 0.276
Δ Heart rate − 0.134 0.435 Δ Heart rate − 0.072 0.669 Δ Heart rate − 0.159 0.311 Δ Heart rate − 0.069 0.654
Δ LDL-cholesterol 0.083 0.615 Δ LDL-cholesterol 0.049 0.758 Δ LDL-cholesterol − 0.095 0.531 Δ LDL-cholesterol − 0.118 0.424
Δ Uric acid 0.047 0.809 Δ Uric acid 0.039 0.839 Δ Uric acid 0.046 0.794 Δ Uric acid 0.044 0.803
Δ Systolic BP 0.365 0.049 Δ Systolic BP 0.338 0.038 Δ Systolic BP 0.414 0.016 Δ Systolic BP 0.371 0.014
Δ hsCRP 0.188 0.257 Δ hsCRP 0.235 0.164 Δ hsCRP 0.279 0.070 Δ hsCRP 0.318 0.043
  1. Model 1: Multivariate regression analysis was performed including the parameters sex, age and change of the following parameters under treatment with empagliflozin: HbA1c (model 1), copeptin concentration, hematocrit, 24-h ambulatory heart rate, LDL-cholesterol, uric acid, systolic 24-h ambulatory blood pressure and hsCRP. Model 2 included besides the other previously mentioned parameters fasting plasma glucose instead of HbA1c. LDL-cholesterol low density lipid cholesterol, hsCRP high sensitive C-reactive protein, heart rate 24-h ambulatory heart rate, systolic BP systolic 24-h ambulatory blood pressure, “Δ” refers to the changes due to empagliflozin treatment corrected for the placebo changes
  2. Italic values indicate significance of p-value (p < 0.05)