Table 1 Summary of clinical characteristics between patients with normal versus abnormal endothelial-independent and endothelial-dependent microvascular function
|  | CFRAdn Ratio > 2.5 N = 80 (62%) | CFRAdn Ratio ≤ 2.5 N = 49 (38%) | p value | %ΔCBFAch > 50% N = 78 (60.5%) | %ΔCBFAch ≤ 50% N = 51 (39.5%) | p value |
|---|---|---|---|---|---|---|
Age, years (SD) | 52.8 (10.1) | 55.8 (10.4) | 0.112 | 50.4 (10.9) | 56.2 (9.3) | 0.002 |
Female, n (%) | 41 (51.3%) | 36 (73.5%) | 0.011 | 35 (68.6%) | 42 (53.9%) | 0.092 |
BMI, kg/m2 (SD) | 33.4 (7.6) | 33.9 (7.5) | 0.726 | 33.0 (8.4) | 34.0 (7.0) | 0.497 |
Hypertension, n (%) | 56 (70%) | 30 (61.2) | 0.307 | 32 (62.8) | 54 (69.2) | 0.446 |
Hyperlipidemia, n (%) | 60 (75%) | 37 (75.5%) | 0.948 | 36 (70.6%) | 61 (78.2%) | 0.330 |
History of MI, n (%) | 8 (10.0%) | 8 (16.3%) | 0.579 | 7 (13.7%) | 9 (11.5%) | 0.919 |
History of vascular disease, n (%) | 10 (12.5%) | 4 (8.2) | 0.666 | 7 (13.7) | 7 (9.0%) | 0.597 |
Smoking status, n (%) | ||||||
Never smoked | 31 (38.8%) | 25 (51.0%) | 0.439 | 17 (33.3%) | 39 (50.0%) | 0.152 |
Former smoker | 39 (48.8%) | 20 (40.8%) | Â | 29 (56.9%) | 30 (38.5%) | Â |
Current smoker | 9 (11.3%) | 4 (8.2%) | Â | 5 (9.8%) | 8 (10.3%) | Â |
Total cholesterol, mg/dL (SD) | 179.5 (46.8) | 178.7 (45.9) | 0.922 | 183.2 (49.3) | 176.6 (44.3) | 0.452 |
HDL-C, mg/dL (SD) | 48.6 (16.3) | 47.5 (12.0) | 0.679 | 49.3 (15.5) | 47.4 (14.3) | 0.499 |
LDL-C, mg/dL (SD) | 98.0 (37.3) | 95.8 (38.3) | 0.762 | 100.5 (39.0) | 95.0 (36.6) | 0.444 |
Triglycerides, mg/dL (SD) | 159.6 (103.7) | 171.1 (116.2) | 0.583 | 157.7 (114.5) | 167.8 (104.3) | 0.625 |
Insulin, mg/dL (SD) | 16.4 (26.8) | 36.0 (103.3) | 0.265 | 16.1 (24.9) | 28.7 (83.3) | 0.278 |
BNP, pg/dL (SD) | 57.3 (93.0) | 66.8 (95.3) | 0.695 | 55.7 (89.9) | 64.4 (96.1) | 0.717 |
Heart rate, bpm (SD) | 70.5 (12.2) | 74.7 (13.7) | 0.085 | 72.6 (14.0) | 71.8 (12.2) | 0.748 |
Systolic blood pressure, mmHg (SD) | 136.4 (19.1) | 137.5 (21.1) | 0.784 | 135.3 (21.3) | 137.8 (19.0) | 0.492 |
Diastolic blood pressure, mmHg (SD) | 74.4 (12.8) | 73.8 (15.4) | 0.794 | 73.6 (14.2) | 74.5 (13.7) | 0.727 |
CFRAdn Ratio (SD) | 3.2 (0.6) | 2.2 (0.3) | < 0.001 | 2.9 (0.6) | 2.8 (0.8) | 0.682 |
%ΔCBFAch (SD) | 59.8 (97.8) | 20.7 (75.6) | 0.012 | 130.7 (84.5) | − 11.1 (35.8) | < 0.001 |