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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives

Fig. 3

Intestinal effects of SGLT-1 inhibition by sotagliflozin. By inhibiting SGLT-1 sotagliflozin reduces PPG and improves glycemic control. Possible mechanisms are: (1) delayed glucose absorption in the distal small intestine; (2) consequent increased GLP-1 secretion by L cells, mostly located in the cecum, and (3) delayed glucose in the colon where it could promote changes in microbiota and increase production of SCFAs; the latter seems to independently increase GLP-1 secretion. G glucose, GIP gastric inhibitory peptide, GLP glucagon like peptide, SCFAs short chain fatty acids

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