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Table 4 Discrimination based on multivariable logistic regression models

From: Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

  OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
IGT vs NGT
Sex F 0.39 (0.13–1.18) 0.0963 0.57 (0.21–1.50) 0.2525 0.72 (0.21–2.49) 0.6027 0.56 (0.15–2.13) 0.3925
BMI 1.17 (0.99–1.39) 0.0582 1.20 (1.021.41) 0.0331 1.09 (0.91–1.30) 0.3644 1.14 (0.94–1.38) 0.181
miR-21 1.06 (1.031.10) 0.0004       
HNE    1.01 (0.99–1.03) 0.0638     
SOD2      0.92 (0.860.98) 0.0066   
ROS        3.71 (1.937.11) <0.0001
AUC 0.835   0.717   0.754   0.847  
T2D vs NGT
Sex F 0.61 (0.18–2.05) 0.4241 0.77 (0.17–3.60) 0.7394 0.78 (0.11–5.56) 0.8007 4.00 (0.06–248.71) 0.5108
BMI 1.34 (1.121.59) 0.0012 1.49 (1.161.91) 0.002 1.28 (1.061.55) 0.0115 1.32 (0.89–1.95) 0.1627
Mir21 1.05 (1.011.09) 0.0077       
HNE    1.04 (1.021.06) 0.0001     
SOD2      0.70 (0.570.87) 0.0009   
ROS        12.06 (2.7852.30) 0.0009
AUC 0.812   0.925   0.948   0.977  
  1. The italic values are of statistical significance
  2. Logistic models: ORs/miR-21 are calculated for 0.001 unit increase; ORs/HNE are calculated for 0.1 unit increase; ORs/SOD2 are calculated for 100 unit increase; ORs/ROS are calculated for 0.01 unit increase