Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D

Table 2 Spearman correlation matrix for variables

	miR-21		HNE		SOD2		ROS
	r	p*	r	p*	r	p*	r	p*
Age (years)	0.01	0.9	− 0.009	0.9	− 0.16	0.17	0.03	0.8
BMI (kg/m²)	0.1	0.25	− 0.008	0.9	− *0.3*	*0.008*	0.24	0.02
Fasting PG (mg/dL)	0.16	0.08	*0.35*	*0.0003*	− *0.4*	*0.007*	*0.5*	< *0.0001*
1hPG (mg/dL)	*0.2*	*0.008*	*0.35*	*0.0003*	− *0.4*	*0.007*	*0.6*	< *0.0001*
2hPG (mg/dL)	*0.3*	*0.005*	*0.45*	< *0.0001*	− *0.5*	< *0.0001*	*0.7*	< *0.0001*
HbA1c (%)	0.1	0.2	0.29	0.003	− *0.4*	*0.0003*	*0.5*	< 0.0001
Insulinemia (mIU/L)	*0.22*	*0.02*	0.06	0.5	− *0.3*	*0.0097*	0.2	0.055
HOMA-IR	*0.24*	*0.01*	0.13	0.2	− *0.3*	*0.003*	*0.3*	*0.004*
Cholesterol (mg/dL)	− 0.08	0.4	− 0.09	0.34	0.1	0.4	0.11	0.3
HDL (mg/dL)	− 0.1	0.3	0.11	0.24	*0.3*	*0.003*	− 0.1	0.33
LDL (mg/dL)	− 0.06	0.5	− 0.05	0.64	0.015	0.9	0.04	0.65
TAG (mg/dL)	0.05	0.5	− *0.27*	*0.004*	− 0.15	0.2	0.2	0.05
m-ALB	− 0.004	0.96	0.05	0.6	− 0.02	0.9	*0.3*	*0.0025*
ROS (μmol/min)	*0.2*	*0.0084*	*0.33*	*0.002*	− *0.4*	*0.0006*	–	–
SOD2 (pg/mL)	− *0.34*	*0.002*	− 0.2	0.08	–	–	− *0.4*	*0.0006*
HNE (μg/mL)	0.06	0.55	–	–	− 0.2	0.08	*0.33*	*0.002*

ISSN: 1475-2840