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Table 1 Weight gain, and blood and serum parameters after 8 weeks of treatment in control and diabetic mice

From: SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

  Con (n = 15) DM (n = 15) DM + EM (n = 15) P value
Body weight (g) 25.46 ± 0.70 33.61 ± 1.40* 32.17 ± 1.23* < 0.001
Body weight gain (g) 5.32 ± 0.64 8.05 ± 0.64* 6.61 ± 0.42*# < 0.001
Heart weight (mg) 130.45 ± 5.81 152.37 ± 6.26* 149.13 ± 7.87* < 0.001
Heart weight/Tibial length (mg/mm) 7.73 ± 0.25 8.72 ± 0.32* 8.42 ± 0.27* < 0.001
Blood glucose (mmol/L, fasting) 6.38 ± 0.27 18.83 ± 1.17* 9.27 ± 0.76*# < 0.001
Blood glucose (mmol/L, non-fasting) 8.26 ± 0.38 26.39 ± 1.38* 12.51 ± 1.08*# < 0.001
HbA1c (mmol/mol) 22.93 ± 2.82 94.71 ± 6.52* 39.57 ± 4.95*# < 0.001
Insulin (μg/L) 1.71 ± 0.22 4.92 ± 0.43* 2.69 ± 0.51*# < 0.001
TC (mg/dL) 87.59 ± 3.66 215.89 ± 14.08* 216.35 ± 15.67* < 0.001
HDL-C (mg/dL) 32.76 ± 2.29 73.16 ± 6.51* 75.71 ± 4.71* < 0.001
LDL-C (mg/dL) 40.59 ± 4.92 63.54 ± 6.35* 62.12 ± 5.96* < 0.001
TG (mg/dL) 94.24 ± 6.25 314.87 ± 24.10* 310.47 ± 25.67* < 0.001
  1. Data are expressed as the mean ± SD
  2. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein, LDL-C low-density lipoprotein
  3. *P < 0.05 vs. Con; #P < 0.05 vs. DM