Fig. 2

Progressive cardiac dysfunction in type 2 diabetic heart. Quantitative line graphs showing measures of diastolic function [E/A ratio (a) and deceleration time (DecT, b)], systolic function (ejection fraction (c), fractional shortening (d) and left ventricular (LV) internal diameter at systole (e) and diastole (f)) and wall thickness, (LV anterior wall at systole (g) and diastole (h), LV posterior wall at systole (i) and diastole (j), LV mass (k) relative wall thickness (l). Data are represented as mean ± SEM and n = 8 samples in each group. Two-way ANOVA was used for comparisons between groups at different time points, followed by Tukey’s test for multiple comparisons. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.001 vs. non-diabetic heart of the corresponding age group