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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats

Fig. 1

General effects of MetS rats treated with either DAPA or INSU. a Body weight (left) and blood glucose level of all groups. b Oral glucose tolerance tests (OGTT) by measuring blood glucose levels before and after orogastric gavage of 1 g/kg glucose administration at 15th min, 30th min, 60th min, 120th min to the rats. c The HOMO-IR index determined as described previously [16]. d The systolic (left) and diastolic (right) pressure changes measured from the tail. e Confirmation of DAPA beneficial effect in MetS rats directly targeting the heart by measuring mRNA levels of SGLT2 in tissue homogenates. Data presenting as mean (± SEM) values. The total number of rats/group; n = 15–17. Significance level at *p < 0.05 vs. CON group and #p < 0.05 vs. MetS group

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