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Table 1 Role of adipokines in atherosclerosis

From: Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword

Adipocytokines Role Function References
Adiponectin Protective Improve endothelial dysfunction
Modulate immune response
Promote cholesterol efflux
Polarization of macrophages
AMPK agonist
[80,81,82]
[83]
[84]
[85]
[86]
Vaspin Protective Inhibit ros generation [90]
Apelin Protective Enhance cholesterol efflux [91]
Ometin-1 Protective Reduce activation of inflammatory macrophages [92]
Leptin Detrimental Promote endothelial dysfunction
Promote macrophage infiltration
VSMCS proliferation
[93]
[94]
[97]
Resistin Detrimental Promote endothelial dysfunction
Facilitate macrophage recruitment
[94]
[98]
Chemerin Detrimental Promote endothelial dysfunction
Promote leukocyte recruitment
[95]
[99]
Visfatin Detrimental VSMCS proliferation
Macrophage maturation
Polarization of macrophages
[109]
[114]
[115]
FABP Detrimental Activate inflammatory macrophages [116]
LCN-2 Detrimental Activate inflammatory macrophages [116]