Rising plasminogen activator inhibitor-1 and hypoadiponectinemia characterize the cardiometabolic biomarker profile of women with recent gestational diabetes

Table 3 Significant independent predictors of the respective changes from 1-year to 3-years postpartum in (I) adiponectin, (II) chemerin, (III) RBP-4, (IV) CRP, and (V) PAI-1

Model	Outcome	Significant predictors	Beta	t	P
I	Change in adiponectin	None	n/a	n/a	n/a
II	Change in chemerin	Asian ethnicity	− 10.6690	− 4.06	< 0.0001
II	Change in chemerin	Glucose intolerance at 1-year	6.587417	2.85	0.005
III	Change in RBP-4	Age	0.426114	2.18	0.03
III	Change in RBP-4	Asian ethnicity	− 6.472599	− 2.47	0.01
IV	Change in CRP	Family history of diabetes	− 1.712047	− 3.13	0.002
IV	Change in CRP	Non-white non-Asian ethnicity	1.813425	2.46	0.01
V	Change in PAI-1	GDM	416.1444	2.98	0.003
V	Change in PAI-1	GIGT	338.1283	2.14	0.03

Each model included the following covariates: age, ethnicity, family history of diabetes, BMI at 1-year, duration of breastfeeding, glucose intolerance at 1-year, and gestational glucose tolerance status

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