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Table 1 Characteristics of study population in pregnancy and at 1-year postpartum, stratified into the following 4 groups based on gestational glucose tolerance status: normal GCT NGT, abnormal GCT NGT, GIGT, and GDM

From: Rising plasminogen activator inhibitor-1 and hypoadiponectinemia characterize the cardiometabolic biomarker profile of women with recent gestational diabetes

 

Normal GCT NGT

Abnormal GCT NGT

GIGT

GDM

P

(n = 76)

(n = 99)

(n = 59)

(n = 105)

In pregnancy

 Age (years)

35 ± 4

35 ± 4

34 ± 4

35 ± 4

0.71

 Ethnicity

0.39

  White (%)

75.0

74.7

67.8

65.8

 

  Asian (%)

6.6

9.1

11.9

17.1

 

  Other (%)

18.4

16.2

20.3

17.1

 

 Family history of T2DM (%)

54.0

59.6

64.4

64.8

0.46

 Fasting glucose on OGTT (mmol/L)

4.3 ± 0.4

4.4 ± 0.3

4.6 ± 0.5

4.9 ± 0.7

< 0.0001

 1-h glucose on OGTT (mmol/L)

7.7 ± 1.2

8.4 ± 1.3

10.2 ± 1.3

11.3 ± 1.6

< 0.0001

 2-h glucose on OGTT (mmol/L)

6.7 ± 1.1

7.4 ± 1.0

8.4 ± 1.1

10.4 ± 1.5

< 0.0001

 3-h glucose on OGTT (mmol/L)

5.9 ± 1.2

5.8 ± 1.3

7.2 ± 1.3

8.1 ± 1.7

< 0.0001

At 1-year postpartum

 Months breastfeeding (months)

11 (6–12)

10 (6–12)

9 (4–12)

10 (3–12)

0.36

 BMI (kg/m2)

24.4 (21.5–28.4)

23.6 (21.8–27.8)

25.4 (23.1–30.1)

25.4 (22.5–29.4)

0.12

 Waist circumference (cm)

87 ± 12

85 ± 11

89 ± 13

89 ± 14

0.05

 Fasting glucose on OGTT (mmol/L)

4.6 ± 0.3

4.6 ± 0.4

4.9 ± 0.6

4.9 ± 0.5

< 0.0001

 2-h glucose on OGTT (mmol/L)

5.3 ± 1.2

6.1 ± 1.5

6.4 ± 1.8

7.0 ± 1.9

< 0.0001

 Current glucose tolerance status

< 0.0001

  Normal (%)

97.2

87.4

77.8

69.7

 

  Pre-diabetes/diabetes (%)

2.8

12.6

22.2

30.3

 

 Adiponectin (μg/mL)

10.0 ± 4.0

9.8 ± 3.9

8.2 ± 3.1

8.5 ± 2.9

0.002

 Chemerin (ng/mL)

55.8 ± 12.7

55.3 ± 14.8

58.6 ± 13.9

54.8 ± 16.0

0.48

 RBP-4 (mg/L)

35.8 ± 14.8

37.5 ± 13.3

34.9 ± 10.3

35.3 ± 9.9

0.56

 CRP (mg/L)

1.2 (0.6–3.7)

1.0 (0.5–2.9)

1.3 (0.6–2.7)

1.1 (0.7–3.1)

0.92

 PAI-1 (pg/mL)

7354 (6964–7683)

7308 (6914–7667)

7114 (6558–7612)

7175 (6667–7540)

0.09

  1. P-values refer to overall comparison across the 4 groups by either one-way analysis of variance or Kruskal–Wallis test for continuous variables, or either χ2 or Fisher exact test for categorical variables. Italic indicates P < 0.05