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Table 4 Association of T2D risk related ACE2 SNPs with left heart remodeling

From: ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

ACE2 SNPs LVMI (g/m2) LVEF (%)
Non-diabetic Diabetic P-value Non-diabetic Diabetic P-value
rs1978124
 CC 86.5 ± 14.8 92.3 ± 15.4 0.001 62.3 ± 5.9 58.6 ± 7.6 < 0.001
 TT + CT 88.5 ± 16.7 95.2 ± 17.3 0.006 61.7 ± 7.3 57.7 ± 8.0 < 0.001
 P-value 0.347 0.142   0.579 0.336  
rs2048683
 GG 86.6 ± 14.5 91.9 ± 16.2 0.001 62.0 ± 6.0 59.0 ± 7.3 < 0.001
 TT + GT 89.4 ± 18.6 96.8 ± 16.3 0.013 62.5 ± 7.7 56.7 ± 8.4 < 0.001
 P-value 0.310 0.015   0.698 0.020  
rs2074192
 CC 85.8 ± 15.4 93.3 ± 13.1 < 0.001 62.4 ± 6.1 57.7 ± 7.0 < 0.001
 TT + CT 87.9 ± 15.3 94.2 ± 19.1 0.002 62.0 ± 6.5 58.5 ± 8.5 < 0.001
 P-value 0.273 0.652   0.627 0.412  
rs233575
 CC + CT 85.9 ± 14.1 96.8 ± 15.3 < 0.001 62.8 ± 7.0 56.9 ± 8.3 < 0.001
 TT 87.4 ± 15.7 91.7 ± 16.8 0.012 61.9 ± 6.1 58.9 ± 7.4 < 0.001
 P-value 0.513 0.011   0.382 0.041  
rs4240157
 CC + CT 86.6 ± 13.9 97.7 ± 16.1 < 0.001 62.4 ± 6.6 56.5 ± 8.5 < 0.001
 TT 87.2 ± 15.8 90.5 ± 15.9 0.054 62.0 ± 6.3 59.4 ± 7.0 < 0.001
 P-value 0.766 < 0.001   0.698 0.003  
rs4646156
 AA + AT 90.2 ± 18.1 96.8 ± 16.3 0.020 62.1 ± 7.5 56.7 ± 8.4 < 0.001
 TT 86.3 ± 14.5 91.9 ± 16.2 < 0.001 62.1 ± 6.0 59.0 ± 7.3 < 0.001
 P-value 0.152 0.015   0.967 0.020  
rs4646188
 CC + CT 86.4 ± 16.6 88.1 ± 12.0 0.487 62.0 ± 6.1 61.1 ± 8.2 0.432
 TT 87.5 ± 14.6 95.5 ± 17.1 < 0.001 62.2 ± 6.5 57.2 ± 7.5 < 0.001
 P-value 0.575 < 0.001   0.798 0.001  
rs879922
 CC + CG 89.0 ± 15.0 96.9 ± 16.9 < 0.001 62.2 ± 6.4 57.5 ± 8.9 < 0.001
 GG 85.4 ± 15.5 88.2 ± 13.9 0.147 62.0 ± 6.3 59.3 ± 5.4 0.001
 P-value 0.058 < 0.001   0.758 0.039