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Table 4 Association of T2D risk related ACE2 SNPs with left heart remodeling

From: ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

ACE2 SNPs

LVMI (g/m2)

LVEF (%)

Non-diabetic

Diabetic

P-value

Non-diabetic

Diabetic

P-value

rs1978124

 CC

86.5 ± 14.8

92.3 ± 15.4

0.001

62.3 ± 5.9

58.6 ± 7.6

< 0.001

 TT + CT

88.5 ± 16.7

95.2 ± 17.3

0.006

61.7 ± 7.3

57.7 ± 8.0

< 0.001

 P-value

0.347

0.142

 

0.579

0.336

 

rs2048683

 GG

86.6 ± 14.5

91.9 ± 16.2

0.001

62.0 ± 6.0

59.0 ± 7.3

< 0.001

 TT + GT

89.4 ± 18.6

96.8 ± 16.3

0.013

62.5 ± 7.7

56.7 ± 8.4

< 0.001

 P-value

0.310

0.015

 

0.698

0.020

 

rs2074192

 CC

85.8 ± 15.4

93.3 ± 13.1

< 0.001

62.4 ± 6.1

57.7 ± 7.0

< 0.001

 TT + CT

87.9 ± 15.3

94.2 ± 19.1

0.002

62.0 ± 6.5

58.5 ± 8.5

< 0.001

 P-value

0.273

0.652

 

0.627

0.412

 

rs233575

 CC + CT

85.9 ± 14.1

96.8 ± 15.3

< 0.001

62.8 ± 7.0

56.9 ± 8.3

< 0.001

 TT

87.4 ± 15.7

91.7 ± 16.8

0.012

61.9 ± 6.1

58.9 ± 7.4

< 0.001

 P-value

0.513

0.011

 

0.382

0.041

 

rs4240157

 CC + CT

86.6 ± 13.9

97.7 ± 16.1

< 0.001

62.4 ± 6.6

56.5 ± 8.5

< 0.001

 TT

87.2 ± 15.8

90.5 ± 15.9

0.054

62.0 ± 6.3

59.4 ± 7.0

< 0.001

 P-value

0.766

< 0.001

 

0.698

0.003

 

rs4646156

 AA + AT

90.2 ± 18.1

96.8 ± 16.3

0.020

62.1 ± 7.5

56.7 ± 8.4

< 0.001

 TT

86.3 ± 14.5

91.9 ± 16.2

< 0.001

62.1 ± 6.0

59.0 ± 7.3

< 0.001

 P-value

0.152

0.015

 

0.967

0.020

 

rs4646188

 CC + CT

86.4 ± 16.6

88.1 ± 12.0

0.487

62.0 ± 6.1

61.1 ± 8.2

0.432

 TT

87.5 ± 14.6

95.5 ± 17.1

< 0.001

62.2 ± 6.5

57.2 ± 7.5

< 0.001

 P-value

0.575

< 0.001

 

0.798

0.001

 

rs879922

 CC + CG

89.0 ± 15.0

96.9 ± 16.9

< 0.001

62.2 ± 6.4

57.5 ± 8.9

< 0.001

 GG

85.4 ± 15.5

88.2 ± 13.9

0.147

62.0 ± 6.3

59.3 ± 5.4

0.001

 P-value

0.058

< 0.001

 

0.758

0.039

 
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Cardiovascular Diabetology

ISSN: 1475-2840