WT | WT + AT | WT + AT + CR | db/db | db/db + AT | db/db + AT + CR | |
---|---|---|---|---|---|---|
IVS; d (mm) | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.2 | 0.9 ± 0.1 | 1.1 ± 0.1# | 1 ± 0.1& |
IVS; s (mm) | 1.2 ± 0.1 | 1.2 ± 0.2 | 1.4 ± 0.5 | 1.4 ± 0.2* | 1.6 ± 0.2# | 1.5 ± 0.3* |
LVPW; d (mm) | 0.9 ± 0.1 | 1 ± 0.1 | 0.8 ± 0.1^ | 0.9 ± 0.1 | 1.1 ± 0.2# | 0.9 ± 0.2& |
LVPW; s (mm) | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.2 | 1.5 ± 0.3# | 1.2 ± 0.3& |
LVEDD (mm) | 3.6 ± 0.7 | 4.2 ± 0.4* | 3.5 ± 0.5^ | 3.9 ± 0.2 | 3.5 ± 0.05# | 4.1 ± 0.4& |
LVESD (mm) | 2.9 ± 0.2 | 3.3 ± 0.6 | 1.93 ± 0.8^ | 2.6 ± 0.3* | 2.4 ± 0.6* | 2.5 ± 0.5 |
FS (%) | 33 ± 14 | 21 ± 7* | 46 ± 14^ | 34 ± 7 | 30 ± 7 | 41 ± 10& |
Body weight (g) | 26 ± 3 | 25± 2 | 19 ± 1* | 41 ± 10* | 40 ± 5* | 33 ± 7& |
Heart weight (mg) | 115 ± 2 | 148 ± 3* | 97 ± 2^ | 117 ± 2 | 163 ± 3# | 139 ± 2& |
Systolic blood pressure (mmHg) | 95 ± 21 | 134 ± 29* | 117 ± 13 | 99 ± 30 | 148 ± 15# | 114 ± 11& |
Glucose (mg/dL) | 137 ± 44 | 111 ± 41 | 107 ± 43 | 617 ± 93* | 658 ± 107* | 531 ± 127& |
AST (U/L) | 62 ± 25 | 60 ± 11 | 60 ± 18 | 127 ± 53* | 226 ± 149# | 99 ± 21& |
ALT (U/L) | 126 ± 42 | 130 ± 30 | 127 ± 56 | 182 ± 134 | 281 ± 176* | 117 ± 32& |
Cholesterol (mg/dL) | 79 ± 24 | 101 ± 22* | 8 ± 70^ | 112 ± 21* | 199 ± 91# | 118 ± 25& |
Triglycerides (mg/dL) | 124 ± 57 | 125 ± 25 | 22 ± 82^ | 185 ± 66* | 208 ± 75* | 127 ± 35& |