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Table 1 Metabolic and cardiac phenotype in AT treated mice

From: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

  WT WT + AT WT + AT + CR db/db db/db + AT db/db + AT + CR
IVS; d (mm) 0.8 ± 0.1 0.9 ± 0.1 0.8 ± 0.2 0.9 ± 0.1 1.1 ± 0.1# 1 ± 0.1&
IVS; s (mm) 1.2 ± 0.1 1.2 ± 0.2 1.4 ± 0.5 1.4 ± 0.2* 1.6 ± 0.2# 1.5 ± 0.3*
LVPW; d (mm) 0.9 ± 0.1 1 ± 0.1 0.8 ± 0.1^ 0.9 ± 0.1 1.1 ± 0.2# 0.9 ± 0.2&
LVPW; s (mm) 1.2 ± 0.1 1.1 ± 0.1 1.3 ± 0.1 1.2 ± 0.2 1.5 ± 0.3# 1.2 ± 0.3&
LVEDD (mm) 3.6 ± 0.7 4.2 ± 0.4* 3.5 ± 0.5^ 3.9 ± 0.2 3.5 ± 0.05# 4.1 ± 0.4&
LVESD (mm) 2.9 ± 0.2 3.3 ± 0.6 1.93 ± 0.8^ 2.6 ± 0.3* 2.4 ± 0.6* 2.5 ± 0.5
FS (%) 33 ± 14 21 ± 7* 46 ± 14^ 34 ± 7 30 ± 7 41 ± 10&
Body weight (g) 26 ± 3 25± 2 19 ±  1* 41 ± 10* 40 ± 5* 33 ± 7&
Heart weight (mg) 115 ± 2 148 ± 3* 97 ± 2^ 117 ± 2 163 ± 3# 139 ± 2&
Systolic blood pressure (mmHg) 95 ± 21 134 ± 29* 117 ± 13 99 ± 30 148 ± 15# 114 ± 11&
Glucose (mg/dL) 137 ± 44 111 ± 41 107 ± 43 617 ± 93* 658 ± 107* 531 ± 127&
AST (U/L) 62 ± 25 60 ± 11 60 ± 18 127 ± 53* 226 ± 149# 99 ± 21&
ALT (U/L) 126 ± 42 130 ± 30 127 ± 56 182 ± 134 281 ± 176* 117 ± 32&
Cholesterol (mg/dL) 79 ± 24 101 ± 22* 8 ± 70^ 112 ± 21* 199 ± 91# 118 ± 25&
Triglycerides (mg/dL) 124 ± 57 125 ± 25 22 ± 82^ 185 ± 66* 208 ± 75* 127 ± 35&
  1. Values are mean±SD
  2. IVS;d intra ventricular septum in diastole, IVS;s intra ventricular septum in systole, LVPW;d left ventricle posterior wall in diastole, LVPW;s left ventricle posterior wall in systole, LVESD left ventricle end systolic dimension, LVEDD left ventricle end diastolic dimension, FS fractional shortening, AST aspartate aminotransferase, ALT alanine aminotransferase
  3. *p < 0.05 vs. WT, ^p<0.05 vs.WT+AT, #p<0.05 vs. db/db, &p<0.05 vs. db/db+ AT
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