| |
WT
|
WT + AT
|
WT + AT + CR
|
db/db
|
db/db + AT
|
db/db + AT + CR
|
|---|
|
IVS; d (mm)
|
0.8 ± 0.1
|
0.9 ± 0.1
|
0.8 ± 0.2
|
0.9 ± 0.1
|
1.1 ± 0.1#
|
1 ± 0.1&
|
|
IVS; s (mm)
|
1.2 ± 0.1
|
1.2 ± 0.2
|
1.4 ± 0.5
|
1.4 ± 0.2*
|
1.6 ± 0.2#
|
1.5 ± 0.3*
|
|
LVPW; d (mm)
|
0.9 ± 0.1
|
1 ± 0.1
|
0.8 ± 0.1^
|
0.9 ± 0.1
|
1.1 ± 0.2#
|
0.9 ± 0.2&
|
|
LVPW; s (mm)
|
1.2 ± 0.1
|
1.1 ± 0.1
|
1.3 ± 0.1
|
1.2 ± 0.2
|
1.5 ± 0.3#
|
1.2 ± 0.3&
|
|
LVEDD (mm)
|
3.6 ± 0.7
|
4.2 ± 0.4*
|
3.5 ± 0.5^
|
3.9 ± 0.2
|
3.5 ± 0.05#
|
4.1 ± 0.4&
|
|
LVESD (mm)
|
2.9 ± 0.2
|
3.3 ± 0.6
|
1.93 ± 0.8^
|
2.6 ± 0.3*
|
2.4 ± 0.6*
|
2.5 ± 0.5
|
|
FS (%)
|
33 ± 14
|
21 ± 7*
|
46 ± 14^
|
34 ± 7
|
30 ± 7
|
41 ± 10&
|
|
Body weight (g)
|
26 ± 3
|
25± 2
|
19 ± 1*
|
41 ± 10*
|
40 ± 5*
|
33 ± 7&
|
|
Heart weight (mg)
|
115 ± 2
|
148 ± 3*
|
97 ± 2^
|
117 ± 2
|
163 ± 3#
|
139 ± 2&
|
|
Systolic blood pressure (mmHg)
|
95 ± 21
|
134 ± 29*
|
117 ± 13
|
99 ± 30
|
148 ± 15#
|
114 ± 11&
|
|
Glucose (mg/dL)
|
137 ± 44
|
111 ± 41
|
107 ± 43
|
617 ± 93*
|
658 ± 107*
|
531 ± 127&
|
|
AST (U/L)
|
62 ± 25
|
60 ± 11
|
60 ± 18
|
127 ± 53*
|
226 ± 149#
|
99 ± 21&
|
|
ALT (U/L)
|
126 ± 42
|
130 ± 30
|
127 ± 56
|
182 ± 134
|
281 ± 176*
|
117 ± 32&
|
|
Cholesterol (mg/dL)
|
79 ± 24
|
101 ± 22*
|
8 ± 70^
|
112 ± 21*
|
199 ± 91#
|
118 ± 25&
|
|
Triglycerides (mg/dL)
|
124 ± 57
|
125 ± 25
|
22 ± 82^
|
185 ± 66*
|
208 ± 75*
|
127 ± 35&
|
- Values are mean±SD
- IVS;d intra ventricular septum in diastole, IVS;s intra ventricular septum in systole, LVPW;d left ventricle posterior wall in diastole, LVPW;s left ventricle posterior wall in systole, LVESD left ventricle end systolic dimension, LVEDD left ventricle end diastolic dimension, FS fractional shortening, AST aspartate aminotransferase, ALT alanine aminotransferase
- *p < 0.05 vs. WT, ^p<0.05 vs.WT+AT, #p<0.05 vs. db/db, &p<0.05 vs. db/db+ AT
