Fig. 4

Obesity and arterial hypertension in β GC-A KO and control mice fed a high-fat diet. a Body weights of β GC-A KO and control littermate mice before (0 weeks) and during 15 weeks of control (normal, ND) or high-fat diet (HFD). b Systolic and diastolic arterial blood pressure levels of β GC-A KO and control mice after 6 weeks of ND or HFD. c, d Left ventricular BNP mRNA expression and plasma BNP levels after 8 weeks of ND or HFD were determined by real-time RT-PCR and ELISA, respectively. e Cyclic GMP contents of islets freshly isolated after 8 weeks of ND or HFD were determined by Radioimmunoassay. n = 7 samples per genotype and condition; *P < 0.05 vs ND