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Table 3 Association of studied polymorphisms with the risk of T2DM compared to control under different genetic models

From: Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease

SNP Genotype distributiona Additive model Dominant model Recessive model
Controls N = 136 Patients N = 136 OR (95% CI) p OR (95% CI) p OR (95% CI) p
ANGPTL8
 rs2278426
  C/C 118 (87) 96 (70.5) 1.0 (reference)     
  C/T 16 (12) 36 (26.5) 2.7 (1.33–3.91) 0.003* 2.73 (1.47–5.06) 0.002* 0.49 (0.08–2.73) 0.68
  T/T 2 (1) 4 (3) 2.4 (0.44–13.71)   (C/C vs. C/T + T/T) (C/C + C/T vs. T/T)
CETP
 rs708272
  GG 44 (32) 62 (45.6) 1.0 (reference)   
  GA 72 (53) 58 (42.6) 0.57 (0.34–0.96) 0.08 1.75 (1.07–2.86) 0.03* 1.29 (0.63–2.61) 0.29
  AA 20 (15) 16 (11.8) 0.56 (0.26–1.21)   (G/G/vs. G/A + A/A) (G/G + G/A vs. A/A)
NOS3
 rs1799983
  GG 117 (86) 84 (61.8) 1.0 (reference)   
  GT 16 (11.7) 46 (33.8) 4.0 (2.12–7.55) < 0.001* 0.26 (0.14–0.47) < 0.0001* 0.48 (0.11–1.99) 0.3
  TT 3 (2.3) 6 (4.4) 2.78 (0.67–11.45)   (G/G vs. G/T + T/T) (G/G +G/T vs. T/T)
  1. * Significant p
  2. aData shown as number of subjects (frequency)