Table 3 Association of studied polymorphisms with the risk of T2DM compared to control under different genetic models
SNP | Genotype distributiona | Additive model | Dominant model | Recessive model | ||||
|---|---|---|---|---|---|---|---|---|
Controls N = 136 | Patients N = 136 | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |
ANGPTL8 | ||||||||
 rs2278426 | ||||||||
  C/C | 118 (87) | 96 (70.5) | 1.0 (reference) | – |  |  |  |  |
  C/T | 16 (12) | 36 (26.5) | 2.7 (1.33–3.91) | 0.003* | 2.73 (1.47–5.06) | 0.002* | 0.49 (0.08–2.73) | 0.68 |
  T/T | 2 (1) | 4 (3) | 2.4 (0.44–13.71) |  | (C/C vs. C/T + T/T) | (C/C + C/T vs. T/T) | ||
CETP | ||||||||
 rs708272 | ||||||||
  GG | 44 (32) | 62 (45.6) | 1.0 (reference) | – |  |  | ||
  GA | 72 (53) | 58 (42.6) | 0.57 (0.34–0.96) | 0.08 | 1.75 (1.07–2.86) | 0.03* | 1.29 (0.63–2.61) | 0.29 |
  AA | 20 (15) | 16 (11.8) | 0.56 (0.26–1.21) |  | (G/G/vs. G/A + A/A) | (G/G + G/A vs. A/A) | ||
NOS3 | ||||||||
 rs1799983 | ||||||||
  GG | 117 (86) | 84 (61.8) | 1.0 (reference) | – |  |  | ||
  GT | 16 (11.7) | 46 (33.8) | 4.0 (2.12–7.55) | < 0.001* | 0.26 (0.14–0.47) | < 0.0001* | 0.48 (0.11–1.99) | 0.3 |
  TT | 3 (2.3) | 6 (4.4) | 2.78 (0.67–11.45) |  | (G/G vs. G/T + T/T) | (G/G +G/T vs. T/T) | ||