Influence of micro- and macro-vascular disease and Tumor Necrosis Factor Receptor 1 on the level of lower-extremity amputation in patients with type 2 diabetes

Table 4 Cox multivariate analysis for the risk of major amputation

	Maximal model		Final model
	HR (95% CI)	p value	HR (95% CI)	p value
Sex (ref. women)	3.81 (1.67–8.71)	0.001	3.65 (1.62–8.23)	0.002
Age (per year)	1.02 (0.98–1.06)	0.172
SBP (mmHg)	1.01 (1.00–1.03)	0.011	1.02 (1.00–1.03)	0.004
Diabetes duration (per year)	1.00 (0.97–1.03)	0.655
eGFR, ml min⁻¹ (1.73 m)⁻²	1.00 (0.98–1.03)	0.406
uACR (reference < 3 mg/mmol)^a		0.471
3–30	1.09 (0.45–2.61)
> 30	1.66 (0.66–4.17)
Severe diabetic retinopathy (vs. no)	1.03 (0.48–2.21)	0.943
Macular edema (vs. no)	0.78 (0.32–1.92)	0.600
History of PAD (vs. no)	6.91 (3.75–12.72)	< 0.0001	6.93 (3.78–12.72)	< 0.0001
TNFR1 (per 10 * log pg/ml)	1.28 (1.05–1.57)	0.014	1.29 (1.18–1.42)	< 0.0001
ANGPTL2 (per 10 * log ng/ml)	1.09 (0.91–1.32)	0.333

Variables associated with major amputation at p < 0.05 in the univariate Cox model were selected for the multivariate ‘maximal model’. The ‘final model’ was determined using multiple backwards stepwise regression analysis applied to the ‘maximal model’. Italic data indicate p values below the statistical significance threshold
SBP systolic blood pressure, uACR urinary albumin-to-creatinine ratio
^aMissing data at baseline for 149 patients

ISSN: 1475-2840