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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction

Fig. 1

Schematic of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis. Left: Stanniocalcin-2 inhibits PAPP-A cleavage of IGFBP-4 thereby resulting in decreased levels of free IGF, and consequently decreased IGF signaling. Right: in the absence of Stanniocalcin-2, PAPP-A cleaves IGFBP-4, resulting in liberation of free IGF. Because free IGF can bind its receptor, IGF signaling is then induced. STC-2 Stanniocalcin-2, PAPP-A pregnancy-associated plasma protein-A, IGFBP-4 insulin-like growth factor binding protein 4, IGF insulin-like growth factor

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