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Table 1 General and metabolic characteristics

From: SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice

Variable

Con

Con + dapa

Db

Db + dapa

Weekly food intake (g)

20.6 ± 0.3

23.9 ± 0.2

37.6 ± 1.7#†

49.8 ± 2.4*

Weight gain (g)

3.8 ± 0.4

2.5 ± 0.4

− 5.2 ± 1.4*

5.4 ± 0.8‡†

Subcutaneous Fat (g)

906 ± 70

938 ± 111

3415 ± 339*

4357 ± 204*

Epididymal Fat (g)

1055 ± 63

1117 ± 119

2085 ± 211#†

2442 ± 102#†

Mesenteric fat (g)

541 ± 35

581 ± 44

957 ± 123*

1331 ± 92*

PVAT (g)

30 ± 2

26 ± 2

36 ± 5

47±5*

  1. Values are mean ± SEM
  2. PVAT perivascular adipose tissue; n = 11–12/group
  3. * p < 0.05 vs all other groups
  4. #p < 0.05 vs Con
  5. †p < 0.05 vs Con + dapa
  6. ‡p < 0.05 vs Db
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Cardiovascular Diabetology

ISSN: 1475-2840