| |
All
|
Completers with data
|
|---|
|
N
|
Mean (SD) or ± SE
|
N
|
Mean (SD) or ± SE
|
|---|
|
Age (years)
|
|
CCI-all educationa
|
262
|
54 (8)
|
218
|
54 (8)
|
|
Usual carea
|
87
|
52 (10)
|
78
|
52 (10)
|
|
CCI-all vs. usual careb
| |
1 ± 1
| |
2 ± 1*
|
|
Female (%)
|
|
CCI-all educationa
|
262
|
66.8 ± 2.9
|
218
|
65.1 ± 3.2
|
|
Usual carea
|
87
|
58.6 ± 5.3
|
78
|
60.3 ± 5.5
|
|
CCI-all vs. usual careb
| |
8.2 ± 6.0
| |
4.9 ± 6.4
|
|
Smokers (%)
|
|
CCI-all educationa
|
211
|
3.8 ± 1.3
|
176
|
4.0 ± 1.5
|
|
Usual carea
|
87
|
14.9 ± 3.8
|
78
|
14.1 ± 3.9
|
|
CCI-all vs. usual careb
| |
− 11.2 ± 4.0†
| |
− 10.1 ± 4.2*
|
|
Weight-clinic (kg)
|
|
CCI-all educationa
|
257
|
116.5 (25.9)
|
184
|
115.4 (24.6)
|
|
Usual carea
|
83
|
105.6 (22.2)
|
69
|
106.8 (22.2)
|
|
CCI-all vs. usual careb
| |
10.9 ± 2.9‡
| |
8.6 ± 3.2†
|
|
BMI (kg m−2)
|
|
CCI-all educationa
|
257
|
40.4 (8.8)
|
184
|
39.9 (7.9)
|
|
Usual carea
|
83
|
36.7 (7.3)
|
69
|
37.1 (7.6)
|
|
CCI-all vs. usual careb
| |
3.7 ± 1.0‡
| |
2.7 ± 1.1†
|
|
Hemoglobin A1c (%)
|
|
CCI-all educationa
|
262
|
7.60 (1.50)
|
204
|
7.49 (1.40)
|
|
Usual carea
|
87
|
7.64 (1.76)
|
72
|
7.74 (1.82)
|
|
CCI-all vs. usual careb
| |
−0.04 ± 0.21
| |
−0.25 ± 0.24
|
|
Systolic blood pressure (mmHg)
|
|
CCI-all educationa
|
260
|
132 (14)
|
187
|
133 (15)
|
|
Usual carea
|
79
|
130 (14)
|
67
|
129 (13)
|
|
CCI-all vs. usual careb
| |
2 ± 2
| |
4 ± 2*
|
|
Diastolic blood pressure (mmHg)
|
|
CCI-all educationa
|
260
|
82 (8)
|
187
|
82 (8)
|
|
Usual carea
|
79
|
82 (9)
|
67
|
81 (8)
|
|
CCI-all vs. usual careb
| |
0 ± 1
| |
0 ± 1
|
|
ApoB (mg dL−1)
|
|
CCI-all educationa
|
248
|
105 (29)
|
186
|
103 (28)
|
|
Usual carea
|
79
|
107 (28)
|
59
|
106 (30)
|
|
CCI-all vs. usual careb
| |
−2 ± 4
| |
−2
|
|
ApoA1 (mg dL−1)
|
|
CCI-all educationa
|
248
|
146 (28)
|
185
|
146 (29)
|
|
Usual carea
|
79
|
149 (22)
|
59
|
148 (21)
|
|
CCI-all vs. usual careb
| |
−3 ± 3
| |
−2 ± 3
|
|
ApoB/ApoA1 ratio
|
|
CCI-all educationa
|
248
|
0.74 (0.23)
|
185
|
0.73 (0.23)
|
|
Usual carea
|
79
|
0.73 (0.23)
|
59
|
0.73 (0.25)
|
|
CCI-all vs. usual careb
| |
0.01 ± 0.03
| |
0.00 ± 0.04
|
|
Triglycerides (mg dL−1)
|
|
CCI-all educationa
|
247
|
197 (143)
|
186
|
201 (153)
|
|
Usual carea
|
79
|
283 (401)
|
59
|
297 (458)
|
|
CCI-all vs. usual careb
| |
−86 ± 46*
| |
−97 ± 61
|
|
LDL-C (mg dL−1)
|
|
CCI-all educationa
|
232
|
103 (33)
|
172
|
100 (33)
|
|
Usual carea
|
70
|
102 (36)
|
48
|
100 (38)
|
|
CCI-all vs. usual careb
| |
1 ± 5
| |
0 ± 6
|
|
HDL-C (mg dL−1)
|
|
CCI-all educationa
|
247
|
42 (13)
|
186
|
42 (14)
|
|
Usual carea
|
79
|
38 (11)
|
59
|
37 (11)
|
|
CCI-all vs. usual careb
| |
5 ± 2†
| |
5 ± 2†
|
|
Triglycerides/HDL-C ratio
|
|
CCI-all educationa
|
247
|
5.9 (7.1)
|
186
|
6.1 (7.9)
|
|
Usual carea
|
79
|
10.5 (23.2)
|
59
|
11.5 (26.5)
|
|
CCI-all vs. usual careb
| |
−4.6 ± 2.6
| |
−5.4 ± 3.5
|
|
Large VLDL-P (nmol L−1)
|
|
CCI-all educationa
|
259
|
10 (8)
|
203
|
9 (8)
|
|
Usual carea
|
83
|
12 (12)
|
68
|
12 (13)
|
|
CCI-all vs. usual careb
| |
−2 ± 1
| |
−2 ± 2
|
|
Total LDL-P (nmol L−1)
|
|
CCI-all educationa
|
259
|
1300 (465)
|
203
|
1296 (476)
|
|
Usual carea
|
83
|
1289 (511)
|
68
|
1243 (484)
|
|
CCI-all vs. usual careb
| |
11 ± 63
| |
52 ± 68
|
|
Small LDL-P (nmol L−1)
|
|
CCI-all educationa
|
259
|
774 (377)
|
203
|
778 (378)
|
|
Usual carea
|
83
|
719 (322)
|
68
|
699 (326)
|
|
CCI-all vs. usual careb
| |
55 ± 42
| |
789 ± 48
|
|
LDL-particle size (nm)
|
|
CCI-all educationa
|
259
|
20.30 (0.55)
|
201
|
20.3 (0.55)
|
|
Usual carea
|
83
|
20.33 (0.56)
|
68
|
20.32 (0.55)
|
|
CCI-all vs. usual careb
| |
−0.03 ± 0.07
| |
−0.03 ± 0.08
|
|
Total HDL-P (μmol L−1)
|
|
CCI-all educationa
|
259
|
31.3 (6.4)
|
203
|
31.7 (6.4)
|
|
Usual carea
|
83
|
29.9 (5.8)
|
68
|
30.2 (6.0)
|
|
CCI-all vs. usual careb
| |
1.4 ± 0.8
| |
1.5 ± 0.9
|
|
Large HDL-P (μmol L−1)
|
|
CCI-all educationa
|
259
|
4.3 (2.5)
|
203
|
4.2 (2.5)
|
|
Usual carea
|
83
|
3.8 (2.1)
|
68
|
3.8 (2.1)
|
|
CCI-all vs. usual careb
| |
0.4 ± 0.3
| |
0.4 ± 0.3
|
|
LP-IR score
|
|
CCI-all educationa
|
259
|
72 (17)
|
203
|
72 (18)
|
|
Usual carea
|
83
|
75 (16)
|
68
|
74 (17)
|
|
CCI-all vs. usual careb
| |
−3 ± 2
| |
−2 ± 2
|
|
C-reactive protein (mg L−1)
|
|
CCI-all educationa
|
249
|
8.5 (14.5)
|
193
|
9.0 (16.1)
|
|
Usual carea
|
85
|
8.9 (8.6)
|
70
|
9.1 (9.0)
|
|
CCI-all vs. usual careb
| |
−0.3 ± 1.3
| |
−0.1 ± 1.6
|
|
WBC
|
|
CCI-all educationa
|
260
|
7.2 (1.9)
|
204
|
7.1 (1.8)
|
|
Usual carea
|
86
|
8.1 (2.4)
|
72
|
8.3 (2.4)
|
|
CCI-all vs. usual careb
| |
−0.9 ± 0.3†
| |
−1.2 ± 0.3§
|
|
10-year ASCVD risk (%)
|
|
CCI-all educationa
|
198
|
11.1 (9.1)
|
135
|
12.1 (9.3)
|
|
Usual carea
|
72
|
11.8 (10.8)
|
55
|
11.4 (10.8)
|
|
CCI-all vs. usual careb
| |
−0.6 ± 1.4
| |
0.8 ± 1.6
|
|
CIMT-average (mm)
|
|
CCI-all educationa
|
236
|
0.681 (0.108)
|
144
|
0.692 (0.113)
|
|
Usual carea
|
84
|
0.681 (0.116)
|
68
|
0.680 (0.111)
|
|
CCI-all vs. usual careb
| |
−0.001 ± 0.014
| |
0.013 ± 0.016
|
|
Statin (%)
|
|
CCI-all educationa
|
262
|
50.0 ± 3.1
|
218
|
51.8 ± 3.4
|
|
Usual carea
|
87
|
58.6 ± 5.3
|
73
|
54.8 ± 5.8
|
|
CCI-all vs. usual careb
| |
−8.6 ± 6.1
| |
−3.0 ± 6.7
|
|
Any antihypertensive medication (%)
|
|
CCI-all educationa
|
262
|
67.2 ± 2.9
|
218
|
68.4 ± 3.2
|
|
Usual carea
|
87
|
52.9 ± 5.4
|
73
|
50.7 ± 5.9
|
|
CCI-all vs. usual careb
| |
14.3 ± 6.1*
| |
17.7 ± 6.7†
|
|
ACE or ARB (%)
|
|
CCI-all educationa
|
262
|
29.4 ± 2.8
|
218
|
28.0 ± 3.0
|
|
Usual carea
|
87
|
18.4 ± 4.2
|
73
|
16.4 ± 4.3
|
|
CCI-all vs. usual careb
| |
11.0 ± 5.0*
| |
11.5 ± 5.3*
|
|
Diuretics (%)
|
|
CCI-all educationa
|
262
|
40.8 ± 3.0
|
218
|
41.3 ± 3.3
|
|
Usual carea
|
87
|
29.9 ± 4.9
|
73
|
24.7 ± 5.0
|
|
CCI-all vs. usual careb
| |
11.0 ± 5.8
| |
16.6 ± 6.1†
|
- Significant baseline difference between means or percentages are designated by the following symbols: * 0.05 > P ≥ 0.01, †0.01 > P ≥ 0.001, ‡0.001 > P ≥ 0.0001, §P < 0.0001
- a Mean and standard deviations for continuous variables, percents and standard errors for categorical variables
- b Difference between means or percentages ± 1 standard error of the difference
