Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China

Table 1 Clinical characteristics in control subjects with normal glucose tolerance (NGT), type 2 diabetes (T2DM) patients without atherosclerosis, and T2DM patients with atherosclerosis

Characteristics	Control subjects with NGT (n = 100)	T2DM without atherosclerosis (n = 100)	T2DM with atherosclerosis (n = 100)	P value
Age (years)	56.4 ± 7.6	56.2 ± 8.4	57.2 ± 7.7	0.628
Percent men (%)	54	56	49	0.593
Body mass index (kg/m²)	24.7 ± 3.7	24.4 ± 3.0	25.0 ± 3.6	0.400
Current smoking (%)	21	23	25	0.798
Habitual alcohol drinking (%)	26	22	28	0.611
Leisure-time physical activity (%)	67	52	49	0.023
Statin use (%)	14	32	42	< 0.001
NSAID use (%)	5	34	38	< 0.001
SBP^a	132 ± 15	134 ± 18	134 ± 13	0.398
DBP^a	72 ± 9	75 ± 11	74 ± 12	0.068
TG (mmol/L)^a	1.31 (0.92,1.77)	1.62 (1.07,2.50)	2.04 (1.26,3.41)	< 0.001
TC (mmol/L)^a	4.83 ± 0.90	5.10 ± 0.85	4.94 ± 1.09	0.088
LDL-C (mmol/L)^a	2.88 ± 0.69	3.08 ± 1.06	3.16 ± 0.89	0.082
HDL-C (mmol/L)^a	1.23 ± 0.33	1.16 ± 0.41	1.19 ± 0.33	0.306
Fasting plasma glucose (mmol/L)	4.83 ± 0.63	8.62 ± 1.70	8.09 ± 1.64	< 0.001
Fasting insulin (μU/mL)	6.32 (5.17,8.77)	8.43 (7.09,10.88)	7.83 (5.99,11.06)	< 0.001
HOMA-IR	1.41 (1.05, 1.93)	3.23 (2.45, 4.33)	2.92 (2.13, 3.73)	< 0.001
Duration of diabetes (years)	–	6.7 ± 3.1	7.7 ± 4.4	< 0.001
HbA1c (%)^a	5.1 ± 0.4	7.8 ± 1.3	7.7 ± 1.0	< 0.001
HbA1c (mmol/mol)^a	32.6 ± 4.1	62.0 ± 14.1	60.4 ± 10.7	< 0.001
c-IMT (mm)^a	0.54 ± 0.08	0.74 ± 0.09	0.90 ± 0.14	< 0.001
ANGPTL8^a (pg/mL)	731 ± 285	1360 ± 310	1585 ± 555	< 0.001

Data were expressed as mean ± standard deviation, median (interquartile range), or percentage for continuous various and categorical variables, respectively. Cigarette smoking was defined as having smoked at least 100 cigarettes in one’s lifetime. Regular leisure-time physical activity was defined as participation in ≥ 30 min of moderate or vigorous activity per day at least 3 days per week
^aAdjusted for age, gender, and BMI

ISSN: 1475-2840