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Table 2 List of some selected miR candidates using chemical modification and their delivery

From: Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides

Target miRs miR modification Delivery of therapeutic miRs Pathophysiological role Model system References
miR-16, miR-122, miR-192, miR-194 2′-O-Me Lipid-based Fibrosis Mice [205]
miR-133 2′-O-Me
2′-O-Me
Lipid-based
Lentivirus
Hypertrophy
Metabolic disturbance
Mice
Cardiomyocytes
[144]
[244]
miR-199b 2′-O-Me Lipid-based Fibrosis and functional impairment Mice [285]
miR-34a LNA+PS
LNA
Direct and lipid-based
Lentivirus
Myocardial infarction
Contractile dysfunction
Mice and cardiomyocytes
C57BL/6 mice and cardiomyocytes
[187]
[106]
miR-1 LNA Direct and lipid-based Oxidative stress C57BL/6 mice and cardiomyocytes [188]
miR-208 2′-O-Me
LNA
Lipid-based
Direct
Hypertrophy
Heart failure
Mice
Rat
[139]
[186]
miR-328 2′-O-Me Lipid-based Atrial fibrillation Mice [242]
miR-320 2′-O-Me
2′-O-Me
2′-O-Me
Lipid-based
Lipid-based
Lentivirus
Myocardial infarction
Impaired angiogenesis
Myocardial infarction
Mice
MMVEC
Rat and cardiomyocytes
[286]
[82]
[81]
miR-98 2′-O-Me Adenovirus Hypertrophy Ventricular cardiomyocytes [240]
miR-328 LNA Adenovirus Atrial fibrillation C57BL/6 mice [242]
miR-590 and miR-199a 2′-O-Me AAV and lipid-based Cardiac functional impairment Wistar rats and CD1 mice
Adult ventricular cardiomyocytes
[251]
miR-30c 2′-O-Me AAV Impaired autophagy H9c2 and HEK293 cell
db/db mice
[104]
miR-21 2′-O-Me, 2′-O-F/MOE and LNA
LNA+PS
Lipid-based and direct
Direct
Fibrosis and functional impairment
Fibrosis and cardiac remodeling
Mice
Mice
[287]
[185]
miR-322 2′-O-Me Lentivirus Cardiomyocyte apoptosis Cardiomyocytes [258]
miR-137 2′-O-Me Lentivirus Cardiomyocyte apoptosis Cardiomyocytes [259]
  1. O-Me, O-methyl; LNA, locked nucleic acid; MMVEC, myocardial microvascular endothelial cells; F/MOE, fluro/methoxyethyl; AAV, adeno-associated virus; PS, phosphorothioate