Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides

Ghosh, Nilanjan; Katare, Rajesh

doi:10.1186/s12933-018-0684-1

Cardiovascular Diabetology

Table 1 List of some selected miR candidates involved in the progression of DCM

From: Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides

Sl no	miRs	Expression pattern	Regulatory genes	Pathophysiological role	Expression pattern	Expression sight	References
1	miR-1	Downregulation Upregulation	RyR2 GATA4, NRVMs, ET1, ISO, Pim-1	Cardiac hypertrophy, apoptosis, heart failure, arrhythmia, oxidative stress	Cardiac and skeletal muscle	Transgenic mice with AKt overexpression, exercise-induced hypertrophy model in rats (neonatal rat ventricular cardiomyocytes), hypertrophic human atria and ventricles, STZ-diabetic mice, HG-exposed rat cardiomyocytes	[150] [78, 152]
2	miR-1/206	Upregulation	Pim-1, Hsp60	Cardiac apoptosis	Cardiac muscle	STZ-diabetic rat and mouse heart	[281]
3	miR-9	Downregulation	ELAVL1	Cardiac structural damage	Cardiac muscle	Human diabetic heart IHVC	[123]
4	miR-133a	Downregulation	SGK1, IGF-1R, TGF-β1	Cardiac hypertrophy and fibrosis	Cardiac and skeletal muscle	STZ-diabetic mouse heart	[145, 148]
5	miR-21	Upregulation	DUSP8	Cardiac fibrosis	Cardiac muscle	High glucose induced primary NRCFs	[153]
6	miR-29	Upregulation	MCL-1	Cardiac structural damage	Cardiac muscle	ZDF rat heart	[282]
7	miR-34a	Upregulation	BCL-2, SIRT-1	Cardiac apoptosis	Cardiac muscle	H9c2 cells	[26, 108]
8	miR-30d	Upregulation	FOXO-3a	Cardiac pyroptosis	Cardiac muscle	HFD induced rat heart	[121]
9	miR-195	Upregulation	SIRT-1, BCL-2	Cardiac apoptosis	Cardiac muscle	Db/db mice, CEC, STZ- diabetic mouse	[90]
10	miR-141	Upregulation	Slc25a3	Mitochondrial dysfunction	Cardiac muscle	STZ-diabetic mouse	[161]
11	miR-144	Downregulation	Nrf2	Cardiac apoptosis and oxidative stress	Cardiac muscle, hematopoietic cells, vein, spleen, thyroid	STZ-diabetic mouse, high glucose treated cardiomyocyte	[115]
12	miR-208a	Upregulation	GATA4, Thrap-1	Cardiac hypertrophy	Cardiac muscle	STZ-diabetic mouse	[78, 283]
13	miR-320	Upregulation	VEGF-c, IGF-1, IGF-1R, FLK-1	Cardiac apoptosis	Cardiac muscle	Human Right atrial appendage tissue, GK rat cardiomyocyte, MVEC	[81,82,83,84]
14	miR-373	Downregulation	MEF2c	Cardiac hypertrophy and oxidative stress	Cardiac muscle	High glucose induce neonatal rat ventricular cardiomyocytes, STZ- diabetic mouse heart	[150, 151]
15	miR-483-3p	Upregulation	IGF-1, BCL-2	Cardiac apoptosis	Cardiac muscle, pancreatic-βcells and adipose tissue	H9c2 cells, STZ-diabetic mouse heart	[119]
16	miR-451	Upregulation	CAB-39	Cardiac hypertrophy	Cardiac muscle	HFD induced mouse heart	[142]
17	miR-378	Downregulation Upregulation	IGF-1R	Cardiac hypertrophy Cardiac apoptosis	Cardiac muscle and muscle tissues	Rat cardiomyocytes STZ-diabetic mouse heart	[116, 118, 284]

STZ, streptozotocin; HG, high glucose; IHVC, immortalized human ventricular cardiomyocytes; NRCF, neonatal rat cardiac fibroblast; ZFD, zucker diabetic fatty rat; HFD, high fat diet; GK, Goto–Kakizaki; CEC, cardiac endothelial cells; MVEC, micro vascular endothelial cells

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ISSN: 1475-2840

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