Fig. 4From: Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotidesIsomeric configuration phosphorothioate modification. Formation of diastereomers by phosphorothioate (PS) backbone modifications. a, b Chiral arrangements of Sp and Rp diastereomers. c, d Formation of 3′-phosphorothioate and 5′-phosphorothioate inter-nucleotide linkage from Sp and Rp diastereomersBack to article page