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Table 5 Crude and adjusted hazard ratios in PCOS OUH and development of CVD

From: Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

  CVD CVD (HT and DL excluded)
Crude HR (95% CI) n Age and BMI
Adjusted HRa (95% CI)
Crude HR (95% CI) n Age and BMI
Adjusted HRa (95% CI)
Age (years) 1.1 (1.1; 1.1)
P < 0.001
1076 1.1 (1.1; 1.1)
P < 0.001
1.1 (1.1; 1.1)
P < 0.001
1076 1.1 (1.1; 1.1)
P < 0.001
BMI (kg/m2) 1.1 (1.0; 1.1)
P < 0.001
1076 1.1 (1.1; 1.1)
P < 0.001
1.1 (1.0; 1.1)
P < 0.001
1076 1.1 (1.1; 1.1)
P < 0.001
Waist (cm) 1.0 (1.0;1.0)
P < 0.001
710 1.0 (1.0; 1.0)
P = 0.02
1.0 (1.0;1.0)
P = 0.004
710 1.0 (1.0; 1.1)
P = 0.61
Systolic BP (mmHg) 1.0 (1.0; 1.1)
p < 0.001
730 1.0 (1.0; 1.0)
p < 0.001
1.0 (1.0; 1.1)
P = 0.001
730 1.0 (1.0; 1.0)
P = 0.09
Diastolic BP (mmHg) 1.1 (1.0; 1.1)
P < 0.001
729 1.0 (1.0; 1.1)
P < 0.001
1.1 (1.0; 1.1)
P < 0.001
729 1.0 (1.0; 1.1)
P = 0.06
LDL (mmol/l) 1.8 (1.6; 2.1)
P < 0.001
804 1.5 (1.2; 1.7)
P < 0.001
1.3 (1.0; 1.8)
P = 0.06
804 1.1 (0.7; 1.5)
P = 0.78
Cholesterol (mmol/L) 1.8 (1.6; 2.1)
P < 0.001
815 1.5 (1.3; 1.7)
P < 0.001
1.4 (1.0; 1.8)
P < 0.02
815 1.1 (0.8; 1.5)
P = 0.41
Triglycerides (mmol/L) 1.7 (1.4; 2.0)
P < 0.001
805 1.5 (1.2; 1.7)
P < 0.001
1.3 (0.9; 1.8)
P = 15
805 1.1 (0.7; 1.6)
P = 0.63
Prolactin (µg/L) 0.96 (0.9; 1.0)
P = 0.02
891 0.99 (0.95; 1.02)
P = 0.61
1.0 (0.9; 1.1)
P = 0.89
891 1.0 (1.0; 1.1)
P = 0.33
HbA1c (mmol/mol) 1.0 (1.0; 1.0)
P = 0.30
525 1.0 (1.0; 1.0)
P = 0.73
1.0 (1.0; 1.0)
P = 0.64
525 1.0 (1.0; 1.0)
P = 0.81
Fasting blood glucose (mmol/L) 1.5 (1.3; 1.8)
P < 0.001
510 1.3 (1.1; 1.5)
P = 0.001
1.5 (1.2; 2.0)
P = 0.001
510 1.2 (1.0; 1.7)
P = 0.15
2 h blood glucose (mmol/L) 1.2 (1.1; 1.3)
P < 0.001
497 1.1 (1.1; 1.2)
P < 0.001
1.2 (1.1; 1.3)
P = 0.003
497 1.1 (1.0; 1.2)
P = 0.12
Fasting insulin (pmol/L) 1.0 (1.0; 1.0)
P < 0.001
533 1.0 (1.0; 1.0)
P = 0.007
1.0 (1.0; 1.0)
P = 0.32
533 1.0 (1.0; 1.0)
P = 0.82
HOMA-ir (µg/L) 1.0 (1.0; 1.0)
P < 0.001
509 1.0 (1.0; 1.0)
P = 0.001
1.0 (1.0; 1.0)
P = 0.13
509 1.0 (1.0; 1.0)
P = 0.81
Total testosterone (nmol/L) 0.9 (0.8; 1.1)
P = 0.25
772 1.0 (0.9; 1.2)
P = 0.99
0.9 (0.7; 1.3)
P = 0.72
772 1.0 (0.8; 1.4)
P = 0.89
SHBG (nmol/L) 1.0 (1.0; 1.0)
P = 0.43
1000 1.0 (1.0; 1.0)
P = 0.30
1.0 (1.0; 1.0)
P = 0.77
1000 1.0 (1.0; 1.0)
P = 0.23
Free testosterone (nmol/L) 0.75 (0.01; 39.37)
P = 0.89
759 1.9 (0.03; 112.8)
P = 0.75
0.0 (0.0; 338.2)
P = 0.26
759 0.0 (0.0; 1858.0)
P = 0.36
  1. Baseline characteristics in PCOS OUH and risk of development of CVD
  2. Hazard ratios are presented for crude models and models corrected for age and BMI
  3. BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h: 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG: Sex hormone-binding globulin
  4. aExcept age which is adjusted for BMI alone, and BMI which is adjusted for age alone