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Table 5 Crude and adjusted hazard ratios in PCOS OUH and development of CVD

From: Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

  CVD CVD (HT and DL excluded)
Crude HR (95% CI) n Age and BMI Adjusted HRa (95% CI) Crude HR (95% CI) n Age and BMI Adjusted HRa (95% CI)
Age (years) 1.1 (1.1; 1.1) P < 0.001 1076 1.1 (1.1; 1.1) P < 0.001 1.1 (1.1; 1.1) P < 0.001 1076 1.1 (1.1; 1.1) P < 0.001
BMI (kg/m2) 1.1 (1.0; 1.1) P < 0.001 1076 1.1 (1.1; 1.1) P < 0.001 1.1 (1.0; 1.1) P < 0.001 1076 1.1 (1.1; 1.1) P < 0.001
Waist (cm) 1.0 (1.0;1.0) P < 0.001 710 1.0 (1.0; 1.0) P = 0.02 1.0 (1.0;1.0) P = 0.004 710 1.0 (1.0; 1.1) P = 0.61
Systolic BP (mmHg) 1.0 (1.0; 1.1) p < 0.001 730 1.0 (1.0; 1.0) p < 0.001 1.0 (1.0; 1.1) P = 0.001 730 1.0 (1.0; 1.0) P = 0.09
Diastolic BP (mmHg) 1.1 (1.0; 1.1) P < 0.001 729 1.0 (1.0; 1.1) P < 0.001 1.1 (1.0; 1.1) P < 0.001 729 1.0 (1.0; 1.1) P = 0.06
LDL (mmol/l) 1.8 (1.6; 2.1) P < 0.001 804 1.5 (1.2; 1.7) P < 0.001 1.3 (1.0; 1.8) P = 0.06 804 1.1 (0.7; 1.5) P = 0.78
Cholesterol (mmol/L) 1.8 (1.6; 2.1) P < 0.001 815 1.5 (1.3; 1.7) P < 0.001 1.4 (1.0; 1.8) P < 0.02 815 1.1 (0.8; 1.5) P = 0.41
Triglycerides (mmol/L) 1.7 (1.4; 2.0) P < 0.001 805 1.5 (1.2; 1.7) P < 0.001 1.3 (0.9; 1.8) P = 15 805 1.1 (0.7; 1.6) P = 0.63
Prolactin (µg/L) 0.96 (0.9; 1.0) P = 0.02 891 0.99 (0.95; 1.02) P = 0.61 1.0 (0.9; 1.1) P = 0.89 891 1.0 (1.0; 1.1) P = 0.33
HbA1c (mmol/mol) 1.0 (1.0; 1.0) P = 0.30 525 1.0 (1.0; 1.0) P = 0.73 1.0 (1.0; 1.0) P = 0.64 525 1.0 (1.0; 1.0) P = 0.81
Fasting blood glucose (mmol/L) 1.5 (1.3; 1.8) P < 0.001 510 1.3 (1.1; 1.5) P = 0.001 1.5 (1.2; 2.0) P = 0.001 510 1.2 (1.0; 1.7) P = 0.15
2 h blood glucose (mmol/L) 1.2 (1.1; 1.3) P < 0.001 497 1.1 (1.1; 1.2) P < 0.001 1.2 (1.1; 1.3) P = 0.003 497 1.1 (1.0; 1.2) P = 0.12
Fasting insulin (pmol/L) 1.0 (1.0; 1.0) P < 0.001 533 1.0 (1.0; 1.0) P = 0.007 1.0 (1.0; 1.0) P = 0.32 533 1.0 (1.0; 1.0) P = 0.82
HOMA-ir (µg/L) 1.0 (1.0; 1.0) P < 0.001 509 1.0 (1.0; 1.0) P = 0.001 1.0 (1.0; 1.0) P = 0.13 509 1.0 (1.0; 1.0) P = 0.81
Total testosterone (nmol/L) 0.9 (0.8; 1.1) P = 0.25 772 1.0 (0.9; 1.2) P = 0.99 0.9 (0.7; 1.3) P = 0.72 772 1.0 (0.8; 1.4) P = 0.89
SHBG (nmol/L) 1.0 (1.0; 1.0) P = 0.43 1000 1.0 (1.0; 1.0) P = 0.30 1.0 (1.0; 1.0) P = 0.77 1000 1.0 (1.0; 1.0) P = 0.23
Free testosterone (nmol/L) 0.75 (0.01; 39.37) P = 0.89 759 1.9 (0.03; 112.8) P = 0.75 0.0 (0.0; 338.2) P = 0.26 759 0.0 (0.0; 1858.0) P = 0.36
  1. Baseline characteristics in PCOS OUH and risk of development of CVD
  2. Hazard ratios are presented for crude models and models corrected for age and BMI
  3. BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h: 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG: Sex hormone-binding globulin
  4. aExcept age which is adjusted for BMI alone, and BMI which is adjusted for age alone