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Table 5 Crude and adjusted hazard ratios in PCOS OUH and development of CVD

From: Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

 

CVD

CVD (HT and DL excluded)

Crude HR (95% CI)

n

Age and BMI

Adjusted HRa (95% CI)

Crude HR (95% CI)

n

Age and BMI

Adjusted HRa (95% CI)

Age (years)

1.1 (1.1; 1.1)

P < 0.001

1076

1.1 (1.1; 1.1)

P < 0.001

1.1 (1.1; 1.1)

P < 0.001

1076

1.1 (1.1; 1.1)

P < 0.001

BMI (kg/m2)

1.1 (1.0; 1.1)

P < 0.001

1076

1.1 (1.1; 1.1)

P < 0.001

1.1 (1.0; 1.1)

P < 0.001

1076

1.1 (1.1; 1.1)

P < 0.001

Waist (cm)

1.0 (1.0;1.0)

P < 0.001

710

1.0 (1.0; 1.0)

P = 0.02

1.0 (1.0;1.0)

P = 0.004

710

1.0 (1.0; 1.1)

P = 0.61

Systolic BP (mmHg)

1.0 (1.0; 1.1)

p < 0.001

730

1.0 (1.0; 1.0)

p < 0.001

1.0 (1.0; 1.1)

P = 0.001

730

1.0 (1.0; 1.0)

P = 0.09

Diastolic BP (mmHg)

1.1 (1.0; 1.1)

P < 0.001

729

1.0 (1.0; 1.1)

P < 0.001

1.1 (1.0; 1.1)

P < 0.001

729

1.0 (1.0; 1.1)

P = 0.06

LDL (mmol/l)

1.8 (1.6; 2.1)

P < 0.001

804

1.5 (1.2; 1.7)

P < 0.001

1.3 (1.0; 1.8)

P = 0.06

804

1.1 (0.7; 1.5)

P = 0.78

Cholesterol (mmol/L)

1.8 (1.6; 2.1)

P < 0.001

815

1.5 (1.3; 1.7)

P < 0.001

1.4 (1.0; 1.8)

P < 0.02

815

1.1 (0.8; 1.5)

P = 0.41

Triglycerides (mmol/L)

1.7 (1.4; 2.0)

P < 0.001

805

1.5 (1.2; 1.7)

P < 0.001

1.3 (0.9; 1.8)

P = 15

805

1.1 (0.7; 1.6)

P = 0.63

Prolactin (µg/L)

0.96 (0.9; 1.0)

P = 0.02

891

0.99 (0.95; 1.02)

P = 0.61

1.0 (0.9; 1.1)

P = 0.89

891

1.0 (1.0; 1.1)

P = 0.33

HbA1c (mmol/mol)

1.0 (1.0; 1.0)

P = 0.30

525

1.0 (1.0; 1.0)

P = 0.73

1.0 (1.0; 1.0)

P = 0.64

525

1.0 (1.0; 1.0)

P = 0.81

Fasting blood glucose (mmol/L)

1.5 (1.3; 1.8)

P < 0.001

510

1.3 (1.1; 1.5)

P = 0.001

1.5 (1.2; 2.0)

P = 0.001

510

1.2 (1.0; 1.7)

P = 0.15

2 h blood glucose (mmol/L)

1.2 (1.1; 1.3)

P < 0.001

497

1.1 (1.1; 1.2)

P < 0.001

1.2 (1.1; 1.3)

P = 0.003

497

1.1 (1.0; 1.2)

P = 0.12

Fasting insulin (pmol/L)

1.0 (1.0; 1.0)

P < 0.001

533

1.0 (1.0; 1.0)

P = 0.007

1.0 (1.0; 1.0)

P = 0.32

533

1.0 (1.0; 1.0)

P = 0.82

HOMA-ir (µg/L)

1.0 (1.0; 1.0)

P < 0.001

509

1.0 (1.0; 1.0)

P = 0.001

1.0 (1.0; 1.0)

P = 0.13

509

1.0 (1.0; 1.0)

P = 0.81

Total testosterone (nmol/L)

0.9 (0.8; 1.1)

P = 0.25

772

1.0 (0.9; 1.2)

P = 0.99

0.9 (0.7; 1.3)

P = 0.72

772

1.0 (0.8; 1.4)

P = 0.89

SHBG (nmol/L)

1.0 (1.0; 1.0)

P = 0.43

1000

1.0 (1.0; 1.0)

P = 0.30

1.0 (1.0; 1.0)

P = 0.77

1000

1.0 (1.0; 1.0)

P = 0.23

Free testosterone (nmol/L)

0.75 (0.01; 39.37)

P = 0.89

759

1.9 (0.03; 112.8)

P = 0.75

0.0 (0.0; 338.2)

P = 0.26

759

0.0 (0.0; 1858.0)

P = 0.36

  1. Baseline characteristics in PCOS OUH and risk of development of CVD
  2. Hazard ratios are presented for crude models and models corrected for age and BMI
  3. BP blood pressure, LDL low density lipoprotein, HDL high density lipoprotein, 2 h: 2 hours (during oral glucose tolerance test), HOMA-ir homeostasis model assessment of insulin resistance, SHBG: Sex hormone-binding globulin
  4. aExcept age which is adjusted for BMI alone, and BMI which is adjusted for age alone
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Cardiovascular Diabetology

ISSN: 1475-2840