From: Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus
Completed n = 254 | Loss to FU n = 20 | p value | |
---|---|---|---|
Demographic and clinical characteristics | |||
Age (years) | 70.9 ± 4.3 | 72 ± 5.1 | 0.341 |
Male gender (n, %) | 142 (55.9) | 8 (40.0) | 0.389 |
Weight (kg) | 85.8 ± 17.3 | 85.7 ± 16.7 | 0.820 |
BMI (kg/m2) | 30.2 ± 5.9 | 31.1 ± 5.6 | 0.536 |
Waist circumference (cm) | 103.1 ± 13.3 | 107.3 ± 15.3 | 0.255 |
Obesity (n, %) | 124 (48.8) | 11 (55.0) | 0.811 |
Heart rate (n/min) | 69 ± 11 | 71 ± 13 | 0.445 |
Systolic blood pressure (mmHg) | 139 ± 14 | 141 ± 23 | 0.550 |
Diastolic blood pressure (mmHg) | 81 ± 10 | 80 ± 10 | 0.613 |
Hypertension (n, %) | 190 (74.8) | 14 (70.0) | 0.195 |
Family history of HF (n, %) | 73 (28.7) | 7 (35.0) | 0.518 |
Past chemotherapy (n, %) | 22 (8.7) | 3 (15.0) | 0.403 |
Past heart disease (n, %) | 14 (5.5) | 2 (10.0) | 0.103 |
HbA1c (mmol/mol) | 53.4 ± 10.2 | 54.2 ± 9.5 | 0.733 |
HbA1c > 64 mmol/mol (n, %) | 32 (12.6) | 4 (20) | 0.245 |
Medication | |||
Insulin (n, %) | 60 (23.6) | 5 (25.0) | 0.037 |
Metformin (n, %) | 175 (68.9) | 9 (45.0) | 0.244 |
ACEi/ARB (n, %) | 171 (67.3) | 12 (60.0) | 0.630 |
Beta-blockers (n, %) | 15 (5.9) | 0 (0) | < 0.001 |
Calcium antagonists (n, %) | 62 (24.3) | 2 (10.0) | 0.093 |
Diuretics (n, %) | 27 (10.6) | 4 (20.0) | 0.445 |
Lipid lowering meds (n, %) | 123 (48.4) | 10 (50.0) | 0.560 |
Questionnaire | |||
PHQ-9 score | 3.2 ± 4.3 | 2.8 ± 5.1 | 0.787 |
0–4 | 194 (76.4) | 16 (80.0) | 0.508 |
5–9 | 35 (13.8) | 2 (10.0) | 0.633 |
10–20 | 24 (9.4) | 1 (5.0) | 0.185 |
≥ 20 | 1 (0.4) | 1 (5.0) | 0.011 |
Echocardiography | |||
LVEF (%) | 63.1 ± 6.5 | 63.0 ± 5.1 | 0.965 |
E wave (m/s) | 0.65 ± 0.16 | 0.74 ± 0.26 | 0.024 |
A wave (m/s) | 0.83 ± 0.19 | 0.88 ± 0.25 | 0.421 |
E/A ratio | 0.79 ± 0.21 | 0.79 ± 0.28 | 0.974 |
e′ (m/s) | 0.08 ± 0.02 | 0.08 ± 0.02 | 0.512 |
E/e′ ratio | 9.2 ± 2.7 | 9.8 ± 3.1 | 0.347 |
E/e′ ratio > 13 (n, %) | 26 (10.2) | 3 (15.0) | 0.086 |
DT (s) | 247.0 ± 52.8 | 244.6 ± 50.7 | 0.844 |
LV mass index (g/m2) | 85.6 ± 19.3 | 86.9 ± 15.4 | 0.735 |
LV mass index (g/m1.7) | 74.5 ± 21.1 | 73.3 ± 17.2 | 0.775 |
LV hypertrophy (n, %)a | 35 (13.8) | 1 (5.9) | 0.354 |