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Table 1 Clinical characteristics of all the patients by Hp genotype

From: Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients

Variable Hp 1-1 Hp 1-2 Hp 2-2 Hp 1-del Hp 2-del Hp del–del P value
N 377 2027 2834 133 306 10
Age (years) 60.71 ± 11.41 59.21 ± 12.21 59.86 ± 12.27 61.10 ± 11.53 58.52 ± 13.59 57.83 ± 9.17 0.0880
Male/female (n) 217/160 1110/917 1493/1341 80/53 173/133 5/5 0.1154
BMI (kg/m2) 24.71 ± 3.31 24.94 ± 5.52 24.69 ± 3.64 24.83 ± 3.26 24.67 ± 3.80 24.85 ± 1.87 0.5326
Diastolic blood pressure (mmHg) 80 (70, 86) 80 (75, 88) 80 (75, 88) 80 (70, 90) 80 (75, 85) 80 (70, 85) 0.1924
Systolic blood pressure (mmHg) 130 (120, 141) 130 (120, 140) 130 (120, 142) 130 (120, 145) 130 (120, 140) 120 (120, 140) 0.6499
Duration of diabetes (years) 7 (3, 12) 8 (3, 12) 8 (3, 13) 10 (4, 14) 9 (2, 13) 7 (3, 12) 0.4813
HbA1c (%) [mmol/mol] 8.8 (7.2, 10.5) [73 (55, 91)] 8.7 (7.3, 10.4) [72 (56, 90)] 8.6 (7.1, 10.4) [71 (54, 90)] 8.4 (6.9, 10.1) [68 (52, 87)] 8.8 (7.3, 10.4) [73 (56, 90)] 9.1 (6.9, 9.9) [76 (52, 85)] 0.6758
HDL-C (mmol/L) 1.07 (0.89, 1.29) 1.07 (0.90, 1.29) 1.09 (0.92, 1.30) 1.09 (0.91, 1.30) 1.10 (0.91, 1.27) 1.17 (1.09, 1.30) 0.0931
LDL-C (mmol/L) 2.86 (2.31, 3.41) 2.89 (2.31, 3.45) 2.97 (2.42, 3.58) 2.92 (2.34, 3.68) 3.08 (2.43, 3.81) 3.10 (2.33, 3.51) 0.0001
Total cholesterol (mmol/L) 4.60 (3.87, 5.40) 4.60 (3.94, 5.30) 4.70 (4.10, 5.47) 4.67 (4.00, 5.50) 4.80 (4.18, 5.63) 4.82 (3.60, 5.30) 0.0001
Triglycerides (mmol/L) 1.41 (0.98, 2.10) 1.41 (0.96, 2.13) 1.44 (1.00, 2.13) 1.49 (0.97, 1.88) 1.47 (1.00, 2.01) 1.17 (1.09, 1.36) 0.5292
Macroangiopathy disease 296 (78.51%) 1471 (72.57%) 2052 (72.41%) 105 (78.95%) 222 (72.55%) 7 (70.00%) 0.0793
  1. Data are shown as n or mean ± standard deviation or median (interquartile range)
  2. Hp haptoglobin, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  3. P values indicate the significance of differences among common Hp genotypes and clinical traits in subjects without the Hp del allele. P < 0.05 are shown in italics