Table 2 Effect of 4 weeks of linagliptin treatment on body weight, tibia length, and organ weights in wild-type mice
From: DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice
Control (n = 10) | Linagliptin (n = 10) | Statistical significance | |
|---|---|---|---|
Body weight (g) | 27.2 ± 1.4 | 27.0 ± 1.7 | NS |
Tibia length (TL, mm) | 17.0 ± 0.1 | 17.0 ± 0.1 | NS |
Cerebrum/TL (mg/mm) | 20.5 ± 0.2 | 20.4 ± 0.2 | NS |
Cerebellum/TL (mg/mm) | 3.6 ± 0.1 | 3.7 ± 0.1 | NS |
Left ventricle/TL (mg/mm) | 5.6 ± 0.2 | 5.7 ± 0.1 | NS |
Right ventricle/TL (mg/mm) | 1.3 ± 0.1 | 1.4 ± 0.1 | NS |
Kidney/TL (mg/mm) | 9.7 ± 0.1 | 9.2 ± 0.5 | NS |
Subcutaneous fat/TL (mg/mm) | 22.0 ± 1.3 | 18.6 ± 1.5 | NS |
Visceral fat/TL (mg/mm) | 53.8 ± 4.3 | 58.6 ± 4.5 | NS |
Gastrocnemius muscle/TL (mg/mm) | 8.8 ± 0.3 | 8.5 ± 0.1 | NS |