Table 1 Behaviour of serum parameters before and after 2-day treatment with dapagliflozin or hydrochlorothiazide

Plasma glucose (mmol/l)

7.96 ± 2.47

7.43 ± 2.1^b

6.47 ± 1.16 (n = 6)

5.32 ± 0.88

(n = 6)

0.42

Haematocrit (%)

43.0 ± 2.7^b

42.6 ± 3.1^b

40.7 ± 4.1

40.4 ± 2.4

0.52

Total cholesterol (mmol/l)

4.62 ± 0.76

4.72 ± 1.09^b

4.18 ± 0.59

3.87 ± 0.50

0.17

HDL cholesterol (mmol/l)

1.19 ± 0.23

1.24 ± 0.36

1.37 ± 0.24

1.29 ± 0.16

0.30

Triglycerides (mmol/l)

1.40 ± 0.55

1.50 ± 0.81

1.45 ± 0.31

1.16 ± 0.29

0.11

eGFR (ml/min/1.73 m²)

95.7 ± 12.8

93.7 ± 12.6

102.2 ± 6.1

97.8 ± 3.9

0.51

s-sodium (mEq/l)

141.0 ± 2.0

141.1 ± 1.2

139.3 ± 1.9

141.0 ± 2.6

0.13

s-potassium (mEq/l)

4.4 ± 0.3

4.3 ± 0.3

4.5 ± 2.1

4.2 ± 0.4

0.61

s-calcium (mg/dl)

9.6 ± 0.2

9.6 ± 0.3

9.5 ± 0.9

9.7 ± 0.9

0.03

s-chloride (mEq/l)

101.3 ± 2.9

100.3 ± 2.1

101.3 ± 2.9

102.0 ± 0.0

0.17

s-magnesium (mg/dl)

1.92 ± 0.19

2.04 ± 0.17^ab

1.98 ± 0.33

1.90 ± 0.27

0.003

s-osmolarity (mOsm/l)

296 ± 5^b

296 ± 2

290 ± 5

294 ± 7

0.04

Plasma renin activity (ng/ml/h)

0.50 ± 0.33

1.13 ± 0.97^ab

1.09 ± 0.56

4.00 ± 0.06^a

0.001

Aldosterone (pg/ml)

12.0 ± 4.7

14.3 ± 7.0

7.4 ± 4.6

3.9 ± 0.3

0.36

Norepinephrine (nmol/l)

414 [175]^b

424 [73]

517 [419]

473 [413]^a

0.18

Adrenaline (pmol/l)

25 [37]

25 [24]

41 [13]

40 [11]

0.86