| Dapagliflozin (n = 16) | Hydrochlorothiazide (n = 10) | p value (time × treatment interaction) | ||
---|---|---|---|---|---|
Visit 0 | Visit 1 | Visit 0 | Visit 1 | ||
Plasma glucose (mmol/l) | 7.96 ± 2.47 | 7.43 ± 2.1b | 6.47 ± 1.16 (n = 6) | 5.32 ± 0.88 (n = 6) | 0.42 |
Haematocrit (%) | 43.0 ± 2.7b | 42.6 ± 3.1b | 40.7 ± 4.1 | 40.4 ± 2.4 | 0.52 |
Total cholesterol (mmol/l) | 4.62 ± 0.76 | 4.72 ± 1.09b | 4.18 ± 0.59 | 3.87 ± 0.50 | 0.17 |
HDL cholesterol (mmol/l) | 1.19 ± 0.23 | 1.24 ± 0.36 | 1.37 ± 0.24 | 1.29 ± 0.16 | 0.30 |
Triglycerides (mmol/l) | 1.40 ± 0.55 | 1.50 ± 0.81 | 1.45 ± 0.31 | 1.16 ± 0.29 | 0.11 |
eGFR (ml/min/1.73 m2) | 95.7 ± 12.8 | 93.7 ± 12.6 | 102.2 ± 6.1 | 97.8 ± 3.9 | 0.51 |
s-sodium (mEq/l) | 141.0 ± 2.0 | 141.1 ± 1.2 | 139.3 ± 1.9 | 141.0 ± 2.6 | 0.13 |
s-potassium (mEq/l) | 4.4 ± 0.3 | 4.3 ± 0.3 | 4.5 ± 2.1 | 4.2 ± 0.4 | 0.61 |
s-calcium (mg/dl) | 9.6 ± 0.2 | 9.6 ± 0.3 | 9.5 ± 0.9 | 9.7 ± 0.9 | 0.03 |
s-chloride (mEq/l) | 101.3 ± 2.9 | 100.3 ± 2.1 | 101.3 ± 2.9 | 102.0 ± 0.0 | 0.17 |
s-magnesium (mg/dl) | 1.92 ± 0.19 | 2.04 ± 0.17ab | 1.98 ± 0.33 | 1.90 ± 0.27 | 0.003 |
s-osmolarity (mOsm/l) | 296 ± 5b | 296 ± 2 | 290 ± 5 | 294 ± 7 | 0.04 |
Plasma renin activity (ng/ml/h) | 0.50 ± 0.33 | 1.13 ± 0.97ab | 1.09 ± 0.56 | 4.00 ± 0.06a | 0.001 |
Aldosterone (pg/ml) | 12.0 ± 4.7 | 14.3 ± 7.0 | 7.4 ± 4.6 | 3.9 ± 0.3 | 0.36 |
Norepinephrine (nmol/l) | 414 [175]b | 424 [73] | 517 [419] | 473 [413]a | 0.18 |
Adrenaline (pmol/l) | 25 [37] | 25 [24] | 41 [13] | 40 [11] | 0.86 |