Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Table 3 Associations between circulating levels of MMP-1, -2, -3, -9, and -10 and TIMP-1 and PP (pooled data, n = 1517)

	Model	β	95% CI	p-value
MMP-1	1	− 0.81	− 1.48; − 0.15	0.017
	2	− 0.83	− 1.50; − 0.16	0.015
	3	− 1.08	− 1.81; − 0.35	0.004
MMP-2	1	1.31	0.55; 2.07	0.001
	2	1.33	0.55; 2.10	0.001
	3	1.32	0.55; 2.09	0.001
MMP-3	1	0.42	− 0.49; 1.32	0.366
	2	0.41	− 0.50; 1.31	0.378
	3	0.39	− 0.52; 1.30	0.401
MMP-9	1	− 0.55	− 1.20; 0.10	0.099
	2	− 0.59	− 1.25; 0.08	0.084
	3	− 0.71	− 1.40; − 0.01	0.047
MMP-10	1	− 0.31	− 1.01; 0.39	0.383
	2	− 0.37	− 1.09; 0.35	0.318
	3	− 0.39	− 1.11; 0.34	0.296
TIMP-1	1	0.21	− 0.51; 0.93	0.564
	2	0.21	− 0.53; 0.94	0.582

β, standardized regression coefficient: indicates increase in pulse pressure (in mmHg) per 1 SD increase in lnMMPs and lnTIMP-1
CI confidence interval
Model 1: age, sex, duration of diabetes, HbA1c, eGFR, MAP, cohort and double inclusion
Model 2: model 1 + total cholesterol, BMI, smoking, use of antihypertensive medication, and presence of vascular complications
Model 3: model 2 + TIMP-1

ISSN: 1475-2840