Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Table 2 Associations between serum levels of MMP-1, -2, -3, -9, and -10 and TIMP-1 and cfPWV (n = 614)

	Model	β	95% CI	p value
MMP-1	1	− 0.11	− 0.31; 0.08	0.241
	2	− 0.11	− 0.30; 0.08	0.263
	3	− 0.17	− 0.38; 0.03	0.098
MMP-2	1	0.05	− 0.16; 0.26	0.653
	2	0.06	− 0.16; 0.27	0.598
	3	0.07	− 0.15; 0.28	0.533
MMP-3	1	0.28	0.01; 0.54	0.041
	2	0.29	0.02; 0.55	0.037
	3	0.27	0.00; 0.54	0.047
MMP-9	1	0.09	− 0.10; 0.28	0.345
	2	0.09	− 0.11; 0.28	0.397
	3	0.06	− 0.14; 0.26	0.556
MMP-10	1	− 0.07	− 0.26; 0.13	0.493
	2	− 0.04	− 0.25; 0.16	0.673
	3	− 0.06	− 0.26; 0.14	0.568
TIMP-1	1	0.12	− 0.07; 0.32	0.211
	2	0.12	− 0.07; 0.32	0.212

β, standardized regression coefficient: indicates increase in cfPWV (in m/s) per 1 SD increase in lnMMPs and lnTIMP-1
CI confidence interval
Model 1: age, sex, duration of diabetes, HbA1c, eGFR, MAP
Model 2: model 1 + total cholesterol, BMI, smoking, use of antihypertensive medication, and presence of vascular complications
Model 3: model 2 + TIMP-1

ISSN: 1475-2840