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Table 2 Multivariable linear regression analysis showing associations of the HDL anti-inflammatory capacity (determined as fold increase in VCAM-1 expression) with glucose, glycated hemoglobin, paraoxonase-1 activity and inflammation markers

From: The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation

 

Model 1

Model 2

Model 3

β

P value

β

P value

β

P value

A

 

 Age

− 0.118

0.23

0.155

0.120

0.168

0.084

 Sex (men/women)

0.046

0.61

0.103

0.26

0.086

0.335

 Glucose

0.535

< 0.001

0.521

< 0.001

0.499

< 0.001

 PON-1 activity

− 0.240

0.009

  

− 0.192

0.030

 hs-CRP

  

0.232

0.013

0.220

0.016

B

 Age

0.197

0.059

0.241

0.028

0.253

0.018

 Sex (men/women)

0.049

0.63

0.112

0.28

0.093

0.36

 HbA1c

0.395

< 0.001

0.345

0.003

0.326

0.004

 PON-1 activity

− 0.255

0.010

  

− 0.216

0.028

 hs-CRP

  

0.223

0.038

0.211

0.044

  1. A: Model 1: includes age, sex, glucose and PON-1 activity as independent variables. Model 2: includes age, sex, glucose and hs-CRP as independent variables. Model 3: includes age, sex, glucose, PON-1 activity and hs-CRP as independent variables
  2. B: Model 1: includes age, sex, HbA1c and PON-1 activity as independent variables. Model 2: includes age, sex, HbA1c and hs-CRP as independent variables. Model 3: includes age, sex, HbA1c, PON-1 activity and hs-CRP as independent variables
  3. β, standardized regression coefficient; PON-1, paraoxonase-1; HbA1c, glycated hemoglobin; hs-CRP, high sensitivity C-reactive protein; the HDL anti-inflammatory capacity and hs-CRP are loge transformed. A positive association indicates a relationship with lower HDL anti-inflammatory capacity
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Cardiovascular Diabetology

ISSN: 1475-2840