Table 1 Physiological and biochemical parameters of mice treated with vehicle or different doses of liraglutide

Number

5

5

6

5

Food intake (g/day)

4.2 ± 0.2

4.1 ± 0.1

3.8 ± 0.2

4.2 ± 0.1

Water intake (g/day)

4.9 ± 0.2

5.2 ± 0.3

5.7 ± 0.1

4.9 ± 0.2

Initial BW (g)

21.6 ± 0.5

22.6 ± 0.4

22.9 ± 0.2

22.5 ± 0.5

Final BW (g)

22.5 ± 0.6

23.0 ± 0.8

24.8 ± 0.4

25.0 ± 0.4

Pulse rate (beats/min)

704 ± 15

709 ± 10

717 ± 14

707 ± 11

SBP (mmHg)

126 ± 3

123 ± 2

120 ± 5

125 ± 5

DBP (mmHg)

72 ± 7

72 ± 11

66 ± 11

82 ± 11

HbA1c (%)

5.1 ± 0.4

4.8 ± 0.2

4.7 ± 0.2

4.4 ± 0.1

FPG (mg/dL)

111 ± 28

98 ± 9

120 ± 12

112 ± 20

TC (mg/dL)

78 ± 10

67 ± 11

93 ± 5

91 ± 6

TG (mg/dL)

56 ± 3

51 ± 3

48 ± 3

61 ± 3

Active GLP-1 (pmol/L)

1.4 ± 0.2

2.2 ± 0.3

3.6 ± 0.8

8.4 ± 3.9*^†