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Table 2 Comparison of unadjusted risk of heart failure hospitalization in two study cohorts before and after matching

From: Heart failure hospitalization risk associated with use of two classes of oral antidiabetic medications: an observational, real-world analysis

  Overall unmatched cohorts Matched cohorts
DPP4
n = 32,060
SGLT2
n = 5467
DPP4
n = 9798
SGLT2
n = 4899
Follow up length (months)
 Median 23.8 23.0 24.0 22.9
 25th, 75th percentiles 9.7, 32.0 10.6, 28.3 10.5, 32.1 10.5, 30.8
 Maximum 42.9 42.7 42.9 42.7
Exposure to index medication class
 Average number of fills 10.2 11.3 10.4 11.2
 Average number of days covered 359 357 365 354
Patients w/heart failure hospitalization 1734 109 307 96
Proportion of patients w/heart failure hospitalization (%) 5.4 2.0 3.1 2.0
Person-years of follow up, n 58,018 9192 17,981 8228
Event rate (95% CI) per 100 person years 2.99 (2.85–3.13) 1.19 (0.98–1.43) 1.71 (1.53–1.91) 1.17 (0.96–1.43)
HR (95% CI), unadjusted 0.39 (0.32–0.48); p < .001 0.68 (0.54–0.86); p = .001
  1. CI confidence interval, DPP4 dipeptidyl peptidase-4, HR hazard ratio, SGLT2 sodium–glucose co-transporter 2