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Table 2 Biomarkers in relation to risk of fatal and nonfatal cardiovascular events, all-cause mortality and decline in eGFR >30%

From: Symmetric and asymmetric dimethylarginine as risk markers of cardiovascular disease, all-cause mortality and deterioration in kidney function in persons with type 2 diabetes and microalbuminuria

Biomarker

Model

Cardiovascular events (n = 40)

p

All-cause mortality (n = 26)

p

Decline in eGFR > 30% (n = 42)

p

Symmetric dimethylarginine log scale (1 SD = 0.06)

Unadjusted

1.5 (1.2–1.9)

0.001

1.6 (1.2–2.1)

0.001

1.9 (1.3–2.6)

<0.001

Adjusted

1.7 (1.1–2.6)

0.019

2.3 (1.4–3.9)

0.001

2.2 (1.4–3.7)

0.002

Asymmetric dimethylarginine log scale (1 SD = 0.13)

Unadjusted

1.2 (0.8–1.6)

0.38

1.7 (1.2–2.5)

0.002

1.2 (0.8–1.6)

0.29

Adjusted

1.0 (0.7–1.5)

0.93

1.8 (1.2–2.7)

0.006

1.0 (0.7–1.4)

0.85

  1. Values are hazard ratios with 95% confidence intervals, and represent 1 SD increment of log-transformed values of the biomarkers. Adjustment included sex, age, systolic blood pressure, LDL cholesterol, smoking, HbA1c, plasma creatinine, and urinary albumin excretion rate
  2. Italic values indicate significance of p value (p < 0.05)
  3. eGFR estimated glomerular filtration rate