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Table 1 Study endpoints

From: PRotective Effect on the coronary microcirculation of patients with DIabetes by Clopidogrel or Ticagrelor (PREDICT): study rationale and design. A randomized multicenter clinical trial using intracoronary multimodal physiology

Primary

 Decrease in microcirculatory resistance caused by treatment onset (Ticagrelor > Clopidogrel)—mechanistic effect

 Increase in microcirculatory resistance caused PCI (Ticagrelor < Clopidogrel)—protective effect

Secondary

 Myocardial necrosis associated with PCI damage, assessed by cardiac biomarkersa

 Absolute resistance value after PCI

 Incidence of severe microcirculatory impairment defined as IMR > 29 after PCI

Subgroups analysis

 Obese subjects

  1. PCI percutaneous coronary intervention
  2. aThird universal definition of myocardial infarction [40]
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Cardiovascular Diabetology

ISSN: 1475-2840