Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study

Table 3 Results of stepwise multiple linear regression analyses

Parameters	Covariates included in the model	R² for model	Global p	Standardized β	p value
hsCRP		0.096	<0.001
hsCRP	BMI			0.259	<0.001
MMP-8		0.138	<0.001
	hsCRP			0.312	<0.001
	Previous GDM			−0.137	0.025
	TC			0.129	0.036
TIMP-1		0.067	0.003
	Previous GDM			0.157	0.015
	BMI			0.149	0.025
	Heart rate			−0.132	0.044
C1		0.524	<0.001
	Systolic BP			−0.602	<0.001
	Heart rate			−0.347	<0.001
	BMI			0.232	<0.001
	Time after the index pregnancy			−0.095	0.041
C2		0.317	<0.001
	Systolic BP			−0.345	<0.001
	Heart rate			−0.312	<0.001
	BMI			0.286	<0.001
	Age			−0.191	0.001
	Pack-years of smoking			−0.144	0.012
PWV		0.470	<0.001
	Systolic BP			0.534	<0.001
	Age			0.230	<0.001
	F-Insu			0.191	<0.001
	Previous GDM			0.105	0.026
	Time after the index pregnancy			−0.102	0.040

Covariates in these analyses included age, BMI, previous GDM, pack-years of smoking, time after the index pregnancy, heart rate, systolic blood pressure, hsCRP, TC and fasting insulin. Final models include significant covariates only. Standardized β provides a measure of the relative strength of an association, independent of the measurement units. Standardized β and p values are shown only when p < 0.05
BMI body mass index, BP blood pressure, F-Insu fasting insulin, GDM gestational diabetes mellitus, hsCRP high-sensitivity C reactive protein, C1 large artery compliance index, C2 small artery compliance index, PWV pulse wave velocity, MMP-8 matrix metalloproteinase-8

ISSN: 1475-2840