Fig. 1

The Nrf2 activator dh404 improves vascular function in vivo. a Cumulative concentration–response curves to PE (0.001–100 µmol) and b contraction to l-NAME (100 µmol) was measured. *P < 0.05, ***P < 0.001 and ****P < 0.0001 versus WT + vehicle. ^#P < 0.05 versus Akita + vehicle. c Urinary 8-isoprostane (ng/24 h) and d plasma dROMs were measured. e Quantification of superoxide detection by DHE fluorescence imaging in aortas of WT and Akita mice treated with vehicle or Dh404 (3 mg/kg). *P < 0.05 and ***P < 0.001 as indicated. ^#P < 0.05 and ^#P < 0.01 versus WT + vehicle. Data are presented as ±SEM. N = 4–8 per group