Fig. 1From: DPP-4 inhibition has no acute effect on BNP and its N-terminal pro-hormone measured by commercial immune-assays. A randomized cross-over trial in patients with type 2 diabetesSequential cleavage of proBNP to originate BNP, NT-proBNP and their by-products. Biological activity on cardiac function is reported. DPP-4 can cleave the 2 N-terminal residues of proBNP, BNP, and NT-proBNP, generating inactive or less active peptidesBack to article page