Parameters | Betatrophin | P value | |||
---|---|---|---|---|---|
Q1 (n = 138) | Q2 (n = 139) | Q3 (n = 138) | Q4 (n = 138) | ||
Male gender, n (%) | 73 (52.9Â %) | 73 (52.5Â %) | 73 (52.9Â %) | 73 (52.9Â %) | / |
Age (years) | 20.5 ± 3.1 | 20.0 ± 2.8 | 19.8 ± 2.9 | 20.4 ± 2.9 | 0.170 |
Obesity traits | |||||
BMI (kg/m2) | 25.5 ± 5.5 | 24.7 ± 5.2 | 25.9 ± 6.0 | 26.6 ± 5.9 | 0.051 |
WC (cm) | 85.1 ± 13.8 | 83.1 ± 13.5 | 85.2 ± 15.5 | 87.3 ± 15.2 | 0.120 |
Percent body fat | 30.1 ± 10.2 | 29.4 ± 9.5 | 30.2 ± 10.3 | 31.5 ± 10.4 | 0.346 |
Pressures (mm Hg) | |||||
SBP | 115 ± 14.9 | 113 ± 12.1 | 115 ± 13.5 | 116 ± 15.5 | 0.331 |
DBP | 72 ± 10.7 | 73 ± 10.5 | 72.9 ± 9.5 | 75 ± 11.3 | 0.402 |
Lipids (mmol/l) | |||||
TC | 4.27 ± 0.82 | 4.19 ± 0.82 | 4.29 ± 0.79 | 4.65 ± 1.17*,+,$ | <0.001 |
TG | 0.98 ± 0.53 | 1.02 ± 0.44 | 1.17 ± 0.85* | 1.37 ± 1.23*,+ | <0.001 |
LDL-C | 2.49 ± 0.71 | 2.40 ± 0.73 | 2.47 ± 0.66 | 2.77 ± 0.98*,+,$ | <0.001 |
HDL-C | 1.44 ± 0.29 | 1.42 ± 0.31 | 1.43 ± 0.35 | 1.45 ± 0.34 | 0.870 |
Glucose and insulin-related traits | |||||
Glucose0 (mmol/l) | 4.86 ± 0.51 | 4.97 ± 1.12 | 4.89 ± 0.44 | 4.95 ± 0.48 | 0.495 |
Glucose30 (mmol/l) | 7.79 ± 1.33 | 7.99 ± 1.80 | 7.91 ± 1.42 | 8.05 ± 1.43 | 0.545 |
Glucose120 (mmol/l) | 5.92 ± 1.30 | 6.01 ± 2.68 | 6.18 ± 1.45 | 6.15 ± 1.65 | 0.631 |
HbA1c (%) | 5.34 ± 0.37 | 5.42 ± 0.66 | 5.35 ± 0.36 | 5.40 ± 0.48 | 0.515 |
Insulin0 (mU/L)a | 1.91 ± 0.71 | 1.88 ± 0.66 | 1.96 ± 0.74 | 1.98 ± 0.84 | 0.665 |
Insulin30 (mU/L)a | 4.30 ± 0.72 | 4.20 ± 0.63 | 4.31 ± 0.76 | 4.20 ± 0.78 | 0.460 |
Insulin120 (mU/L)a | 3.61 ± 0.79 | 3.53 ± 0.79 | 3.61 ± 0.70 | 3.65 ± 0.90 | 0.661 |
HOMA-IRa | 0.37 ± 0.75 | 0.36 ± 0.70 | 0.43 ± 0.75 | 0.46 ± 0.87 | 0.636 |
ISI aM | 1.79 ± 0.65 | 1.83 ± 0.58 | 1.77 ± 0.65 | 1.79 ± 0.72 | 0.872 |
IGIa | 0.29 ± 0.84 | 0.16 ± 0.76 | 0.26 ± 0.83 | 0.16 ± 0.80 | 0.423 |
DIOa | 2.09 ± 0.87 | 2.00 ± 0.79 | 2.02 ± 0.65 | 1.93 ± 0.77 | 0.436 |
Hepar and renal-related traits | |||||
AST (IU/L)a | 2.91 ± 0.25 | 2.96 ± 0.35 | 2.94 ± 0.28 | 2.97 ± 0.39 | 0.412 |
ALT (IU/L)a | 2.92 ± 0.49 | 2.94 ± 0.52 | 2.95 ± 0.53 | 3.04 ± 0.60 | 0.248 |
Creatinine (umol/L)a | 4.17 ± 0.19 | 4.19 ± 0.23 | 4.19 ± 0.19 | 4.22 ± 0.28 | 0.333 |
Uric acid (umol/L)a | 5.80 ± 0.26 | 5.83 ± 0.25 | 5.86 ± 0.30 | 5.88 ± 0.27 | 0.098 |
Adipokines | |||||
FGF21 (pg/ml)a | 4.41 ± 1.00 | 4.34 ± 1.03 | 4.44 ± 1.16 | 4.41 ± 1.30 | 0.914 |
Adiponectin (μg/mL)a | 1.88 ± 0.65 | 1.94 ± 0.57 | 1.90 ± 0.68 | 1.89 ± 0.75 | 0.885 |
Betatrophin (pg/ml)a | 5.37 ± 0.15 | 5.66 ± 0.09* | 5.82 ± 0.08*,+ | 6.24 ± 0.43*,+,$ | <0.001 |
Vitamin D (ng/ml)a | 2.70 ± 0.36 | 2.70 ± 0.41 | 2.64 ± 0.35 | 2.53 ± 0.47*,+ | 0.003 |