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Table 2 Hemodynamics at baseline and 2 h of reperfusion in experimental rats

From: N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats

  Heart rate (bpm) LVSP (mmHg) +dp/dt (mmHg/s) −dp/dt (mmHg/s)
Baseline (10 min before ischemia)
C 374 ± 14 122 ± 7 6735 ± 643 4839 ± 612
D 313 ± 12# 103 ± 5# 5121 ± 520# 3670 ± 507#
D + NAC 328 ± 15# 114 ± 6 6355 ± 437$ 4635 ± 463$
2 h reperfusion
C 287 ± 11** 91 ± 5** 4658 ± 486* 3240 ± 447*
D 220 ± 13**# 64 ± 4**# 2476 ± 379*# 2134 ± 384*#
D + NAC 235 ± 15**# 87 ± 4**$ 3980 ± 424*$ 3102 ± 337*$
  1. Control (C), diabetic (D) and N-acetylcysteine-treated diabetic rats (1.5 g/kg/day, D+NAC) were subjected to 30 min (min) of left anterior descending coronary artery occlusion followed by reperfusion for 2 h (h). The heart rate, left ventricular systolic pressure (LVSP), left ventricular maximum rate of increase of left ventricular developed pressure (+dp/dt) and maximum rate of decrease of left ventricular developed pressure (−dp/dt) were monitored at 10 min before ischemia (baseline) and 2 h after reperfusion. All the results are expressed as mean ± SD, n = 8. Differences in hemodynamics at baseline and 2 h of reperfusion were determined by using two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test
  2. * P < 0.05
  3. ** P < 0.01 vs. their corresponding baseline
  4. #P < 0.05 vs. their corresponding C group
  5. $P < 0.05 vs. their corresponding D group