N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats

Table 2 Hemodynamics at baseline and 2 h of reperfusion in experimental rats

	Heart rate (bpm)	LVSP (mmHg)	+dp/dt (mmHg/s)	−dp/dt (mmHg/s)
Baseline (10 min before ischemia)
C	374 ± 14	122 ± 7	6735 ± 643	4839 ± 612
D	313 ± 12^#	103 ± 5^#	5121 ± 520^#	3670 ± 507^#
D + NAC	328 ± 15^#	114 ± 6	6355 ± 437^$	4635 ± 463^$
2 h reperfusion
C	287 ± 11**	91 ± 5**	4658 ± 486*	3240 ± 447*
D	220 ± 13**^#	64 ± 4**^#	2476 ± 379*^#	2134 ± 384*^#
D + NAC	235 ± 15**^#	87 ± 4**^$	3980 ± 424*^$	3102 ± 337*^$

Control (C), diabetic (D) and N-acetylcysteine-treated diabetic rats (1.5 g/kg/day, D+NAC) were subjected to 30 min (min) of left anterior descending coronary artery occlusion followed by reperfusion for 2 h (h). The heart rate, left ventricular systolic pressure (LVSP), left ventricular maximum rate of increase of left ventricular developed pressure (+dp/dt) and maximum rate of decrease of left ventricular developed pressure (−dp/dt) were monitored at 10 min before ischemia (baseline) and 2 h after reperfusion. All the results are expressed as mean ± SD, n = 8. Differences in hemodynamics at baseline and 2 h of reperfusion were determined by using two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test
* P < 0.05
** P < 0.01 vs. their corresponding baseline
^#P < 0.05 vs. their corresponding C group
^$P < 0.05 vs. their corresponding D group

ISSN: 1475-2840