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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats

Fig. 2

Effects of N-acetylcysteine treatment on the levels of 15-F2t-IsoP, NO, nitrotyrosine and O2 in diabetic myocardium, as well as NO and O2 levels in isolated cardiomyocytes. Control (C) or STZ-induced diabetic rats were either untreated (D) or treated with antioxidant N-acetylcysteine (1.5 g/kg/day, NAC) by oral gavage for 4 weeks,and adult rats cardiomyocytes were isolated and prepared. ae In situ O2 production in LV sections stained by DHE (a), myocardial levels of 15-F2t-IsoP (b), NO (c), nitrotyrosine (d) and O2 in the absence and presence of L-NAME (e); f, g cardiomyocytes levels of NO (f) and O2 (g) production in the absence and presence of L-NAME. All the results are expressed as mean ± SD, n = 7. Differences of O2 in the absence and presence of L-NAME were determined by using two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test, the others were determined by using one-way ANOVA followed by Tukey’s test. *P < 0.05 vs. all the other groups. MLU, mean light unit

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