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Table 1 Metabolic characteristics of control and WD-fed mice

From: The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice

  Control WD-fed p value
Body weight (g) 23.8 ± 0.8 27.0 ± 1.2 <0.0001*
Tibia length (mm) 17.2 ± 0.4 17.1 ± 0.4 0.66
Caloric intake (g/kg/week) 3.2 ± 0.1 3.8 ± 0.2 <0.0001*
Non-fasting blood glucose (mmol/L) 11.5 ± 1.9 11.8 ± 1.8 0.47
Fasting blood glucose (mmol/L) 6.2 ± 0.8 5.7 ± 0.6 0.18
Heart weight (mg) 103.1 ± 4.0 127.4 ± 16.0 0.01*
Left ventricular weight (mg) 79.5 ± 4.1 102.0 ± 15.8 0.001*
Right ventricular weight (mg) 19.1 ± 2.7 20.8 ± 4.0 0.34
Epididymal adipose tissue (mg) 184.3 ± 32.3 308.0 ± 119.1 0.01*
Perirenal adipose tissue (mg) 50.8 ± 10.2 84.5 ± 48.1 0.07
Epicardial adipose tissue (mg) 2.4 ± 1.0 7.2 ± 6.3 0.05
Plasma insulin (ng/mL) 2.71 ± 1.31 3.16 ± 1.06 0.85
Plasma triglycerides (ng/mL) 0.48 ± 0.05 0.55 ± 0.07 0.40
Plasma free fatty acids (nmol/mL) 0.09 ± 0.02 0.09 ± 0.02 0.51
Oral glucose tolerance test AUC 1549 ± 68 1823 ± 156 0.13
Hyperinsulinemic euglycemic clamp
 Steady state blood glucose (mmoll/L) 5.4 ± 0.2 5.6 ± 0.2 0.42
 Glucose infusion rate (mg/min/kg) 25 ± 2.2 24 ± 2.8 0.73
  1. Metabolic characteristics of control and WD-fed mice. AUC area under the curve. Data are presented as mean ± SD and n = 8–12 per group. Data were analyzed using a Student’s t test for between-group comparisons and 2-way ANOVA with repeated measurements for the oral glucose tolerance test (OGTT)