The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice

Table 1 Metabolic characteristics of control and WD-fed mice

	Control	WD-fed	p value
Body weight (g)	23.8 ± 0.8	27.0 ± 1.2	<0.0001*
Tibia length (mm)	17.2 ± 0.4	17.1 ± 0.4	0.66
Caloric intake (g/kg/week)	3.2 ± 0.1	3.8 ± 0.2	<0.0001*
Non-fasting blood glucose (mmol/L)	11.5 ± 1.9	11.8 ± 1.8	0.47
Fasting blood glucose (mmol/L)	6.2 ± 0.8	5.7 ± 0.6	0.18
Heart weight (mg)	103.1 ± 4.0	127.4 ± 16.0	0.01*
Left ventricular weight (mg)	79.5 ± 4.1	102.0 ± 15.8	0.001*
Right ventricular weight (mg)	19.1 ± 2.7	20.8 ± 4.0	0.34
Epididymal adipose tissue (mg)	184.3 ± 32.3	308.0 ± 119.1	0.01*
Perirenal adipose tissue (mg)	50.8 ± 10.2	84.5 ± 48.1	0.07
Epicardial adipose tissue (mg)	2.4 ± 1.0	7.2 ± 6.3	0.05
Plasma insulin (ng/mL)	2.71 ± 1.31	3.16 ± 1.06	0.85
Plasma triglycerides (ng/mL)	0.48 ± 0.05	0.55 ± 0.07	0.40
Plasma free fatty acids (nmol/mL)	0.09 ± 0.02	0.09 ± 0.02	0.51
Oral glucose tolerance test AUC	1549 ± 68	1823 ± 156	0.13
Hyperinsulinemic euglycemic clamp
Steady state blood glucose (mmoll/L)	5.4 ± 0.2	5.6 ± 0.2	0.42
Glucose infusion rate (mg/min/kg)	25 ± 2.2	24 ± 2.8	0.73

Metabolic characteristics of control and WD-fed mice. AUC area under the curve. Data are presented as mean ± SD and n = 8–12 per group. Data were analyzed using a Student’s t test for between-group comparisons and 2-way ANOVA with repeated measurements for the oral glucose tolerance test (OGTT)

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