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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Fig. 2

TNF-α decreases vascular relaxation in HFD-fed mice. Plasma TNF-α levels (a). Concentration-effect curves to acetylcholine and insulin were performed in endothelium-intact mesenteric resistance arteries of C57Bl/6J and TNF-α KO mice fed with control or HFD diets (b, c). The role of TNF-α on the vasculature was investigated using infliximab in vessels of C57Bl/6J fed with control or HFD diet (d). Results represent the mean ± S.E.M. n = 5–6 in each experimental group. *p < 0.05 vs. C57Bl/6J Control; #p < 0.05 vs. C57Bl/6J HFD

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