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Table 7 Metabolomic HDL traits with an association with rs10911021 in diabetic participants, adjusted for the trait with the lowest p value

From: Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

Trait (mol/l)

Beta-effect (se)

p value

FDR adjusted p value

Concentration of large HDL particles

6.70 × 10−4 (0.01)

0.95

1

Total lipids in large HDL

5.28 × 10−4 (0.01)

0.96

1

Phospholipids in large HDL

4.38 × 10−3 (0.01)

0.74

1

Total cholesterol in large HDL

1.40 × 10−3 (0.01)

0.85

1

Cholesterol esters in large HDL

2.81 × 10−3 (0.01)

0.75

1

  1. Beta-effects corresponding to the minor allele are shown, along with the standard errors. FDR analysis was performed using the Benjamini-Hochberg-Yekutieli method. The trait with the lowest p value (free cholesterol in large HDL) was included in the model for the five other traits found to be associated with rs10911021 in diabetic individuals. No other association were observed
  2. FDR false discovery rate
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Cardiovascular Diabetology

ISSN: 1475-2840