Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

Table 4 Relationship between rs10911021 and risk factors for CHD and T2D in UCLEB in participants with and without T2D

Trait	Number of non-T2D participants	Beta-coefficient in non-T2D participants (se)	p value	Number of T2D participants	Beta- coefficient in T2D participants (se)	p value
BMI (kg/m²)	12,803	−0.032 (0.055)	0.56	1747	−0.055 (0.178)	0.76
Triglycerides (mmol/l)^a	12,022	0.007 (0.007)	0.34	1563	0.030 (0.020)	0.87
Total cholesterol (mmol/l)	12,736	−0.011 (0.016)	0.25	1784	0.026 (0.043)	0.54
HDL cholesterol (mmol/l)	12,493	−0.001 (0.005)	0.86	1757	−0.034 (0.012)	0.0005
LDL cholesterol (mmol/l)	12,385	−0.018 (0.014)	0.21	1607	0.070 (0.037)	0.06
Systolic blood pressure (mmHg)	12,739	0.045 (0.298)	0.88	1783	0.056 (0.794)	0.94
Diastolic blood pressure (mmHg)	12,722	0.052 (0.170)	0.76	1782	−0.510 (0.432)	0.24
Fasting glucose (mmol/l)^a	12,740	0.001 (0.002)	0.61	1670	−0.011 (0.009)	0.21
Insulin (µIU/ml)^a	7732	−0.019 (0.011)	0.09	456	0.039 (0.063)	0.53
Glycated haemoglobin (%)	8711	−0.003 (0.008)	0.73	1317	0.032 (0.040)	0.42

Beta-coefficient and standard error for each trait in those with and without T2D is shown. The beta effect relating to the minor allele is shown
^aVariables were log transformed

ISSN: 1475-2840