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Table 4 Relationship between rs10911021 and risk factors for CHD and T2D in UCLEB in participants with and without T2D

From: Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

Trait Number of non-T2D participants Beta-coefficient in non-T2D participants (se) p value Number of T2D participants Beta- coefficient in T2D participants (se) p value
BMI (kg/m2) 12,803 −0.032 (0.055) 0.56 1747 −0.055 (0.178) 0.76
Triglycerides (mmol/l)a 12,022 0.007 (0.007) 0.34 1563 0.030 (0.020) 0.87
Total cholesterol (mmol/l) 12,736 −0.011 (0.016) 0.25 1784 0.026 (0.043) 0.54
HDL cholesterol (mmol/l) 12,493 −0.001 (0.005) 0.86 1757 −0.034 (0.012) 0.0005
LDL cholesterol (mmol/l) 12,385 −0.018 (0.014) 0.21 1607 0.070 (0.037) 0.06
Systolic blood pressure (mmHg) 12,739 0.045 (0.298) 0.88 1783 0.056 (0.794) 0.94
Diastolic blood pressure (mmHg) 12,722 0.052 (0.170) 0.76 1782 −0.510 (0.432) 0.24
Fasting glucose (mmol/l)a 12,740 0.001 (0.002) 0.61 1670 −0.011 (0.009) 0.21
Insulin (µIU/ml)a 7732 −0.019 (0.011) 0.09 456 0.039 (0.063) 0.53
Glycated haemoglobin (%) 8711 −0.003 (0.008) 0.73 1317 0.032 (0.040) 0.42
  1. Beta-coefficient and standard error for each trait in those with and without T2D is shown. The beta effect relating to the minor allele is shown
  2. aVariables were log transformed