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Fig. 7 | Cardiovascular Diabetology

Fig. 7

From: Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

Fig. 7

Comparison of maximal increases of Ca2+ fluorescence intensity in response to different dose of berberine (50 and 200 mg/kg/day) in cerebral VSMCs isolated from CON, CON + berberine, Diabetic, and diabetic + berberine rats. Chronic administration of 50 mg/kg/day berberine had no obvious effects on maximal increases of Ca2+ fluorescence intensity in CON and diabetic rats, respectively. In addition, chronic administration of 200 mg/kg/day berberine significantly inhibited the Ca2+ releases from RyRs in both CON and diabetic rats, respectively. CON control rats, CON + berberine control rats administrated with berberine, Diabetic diabetic rats, diabetic + berberine diabetic rats administrated with berberine. Values are expressed as mean ± SEM and at least n = 8 cells recorded in each group. *P < 0.05 vs. CON rats and # P < 0.05 vs. diabetic rats

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Cardiovascular Diabetology

ISSN: 1475-2840