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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca2+ handling in smooth muscle cells

Fig. 1

Comparison of contractile response in middle cerebral artery to cumulative superfusion of KCl (a) and 5-hydroxytryptamine (5-HT, b) in CON, CON +100 mg/kg/day berberine, diabetic, and diabetic +100 mg/kg/day berberine rats. Concentration–response relationships of middle cerebral artery were represented as the percentage of luminal diameter relative to the baseline internal diameter. Chronic administration of 100 mg/kg/day berberine significantly inhibited the augmented contractile responsiveness to KCl (a) and 5-HT (b) in diabetic rats, respectively. CON control rats, CON + berberine control rats administrated with berberine (100 mg/kg/day), Diabetic diabetic rats, diabetic + berberine: diabetic rats administrated with berberine (100 mg/kg/day). Values are expressed as mean ± SEM and n = 8 animals in each group. *P < 0.05 vs. CON rats and # P < 0.05 vs. diabetic rats

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Cardiovascular Diabetology

ISSN: 1475-2840