Table 2 Serial changes in clinical and laboratory parameters
| Â | Baseline | 3Â months | 12Â months | P value |
|---|---|---|---|---|
Body weight (kg) | 67.3 ± 14.0 | 67.5 ± 14.1 | 67.9 ± 14.1 | 0.042 |
HbA1c (%) | 7.09 ± 0.81 | 6.68 ± 0.69 | 6.69 ± 0.72 | <0.001 |
FPG (mg/dL) | 139.8 ± 33.0 | 130.2 ± 27.2 | 131.7 ± 29.0 | <0.001 |
IRI (IU) | 11.3 ± 10.1 | 12.4 ± 14.3 | 11.8 ± 11.1 | 0.720 |
HOMA-R | 3.9 ± 3.8 | 3.9 ± 3.8 | 3.9 ± 3.8 | 0.914 |
 Insulin resistance (HOMA-R ≥2.5) (%) | 54.7 | 49.4 | 51.4 |  |
LDL-C (mg/dL) | 100.0 ± 24.2 | 101.4 ± 26.8 | 99.5 ± 28.6 | 0.509 |
HDL-C (mg/dL) | 52.4 ± 14.1 | 51.8 ± 13.4 | 50.0 ± 12.0 | 0.036 |
Triglyceride (mg/dL) | 136.1 ± 77.6 | 131.5 ± 71.8 | 133.6 ± 68.4 | 0.308 |
Uric acid (mg/dL) | 5.9 ± 1.2 | 6.0 ± 1.4 | 5.8 ± 1.3 | 0.054 |
Cr (mg/dL) | 0.86 ± 0.25 | 0.88 ± 0.27 | 0.88 ± 0.30 | <0.001 |
eGFR (mL/min/1.73 m2) | 67.7 ± 18.3 | 66.3 ± 18.3 | 66.6 ± 18.6 | 0.009 |
 eGFR <60 (%) | 35.9 | 40.3 | 35.3 |  |
UACR (mg/g Cr) | 79.8 ± 211.4 | 119.3 ± 483.2 | 100.5 ± 239.9 | 0.693 |
 Micro- or overt-albuminuria (%) | 40.2 | 46.3 | 39.5 |  |