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Table 1 Baseline characteristics of the study population

From: Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

Characteristic Total (n = 135) DM (n = 55) NDM (n = 80) p value
Age in years 66.4 ± 10.9 67.6 ± 10.6 65.5 ± 11.1 0.279
Gender no. (%)   0.711
 Female 45 (33.3 %) 17 (30.9 %) 28 (35 %)  
 Male 90 (66.7 %) 38 (69.1 %) 52 (65 %)  
Cardiovascular risk factors no. (%)
 Arterial hypertension 110 (81.5 %) 50 (90.9 %) 60 (75 %) 0.024
 Hyperlipoproteinemia 71 (52.6 %) 29 (52.7 %) 42 (52.5 %) 0.979
 Family history of CAD 40 (29.6 %) 14 (25.5 %) 16 (20 %) 0.529
 Smoking 29 (21.5 %) 10 (18.2 %) 19 (23.8 %) 0.525
 Body mass index kg/m2 28.4 ± 5.2 30.5 ± 5.4 26.9 ± 4.5 0.001
Medical history no. (%)
 Previous MI (6 months) 40 (29.6 %) 16 (29.1 %) 24 (30 %) 0.910
 Previous bypass 15 (11.1 %) 8 (14.5 %) 7 (8.8 %) 0.404
 Previous stroke 7 (5.2 %) 3 (5.5 %) 4 (5 %) 0.907
 Chronic kidney disease 4 (3.0 %) 2 (3.6 %) 2 (2.5 %) 0.702
Coronary artery disease no. (%)   0.009
 3 vessels 49 (36.3 %) 24 (44.4 %) 25 (31.7 %)  
 2 vessels 37 (27.4 %) 20 (37.0 %) 17 (21.5 %)  
 1 vessel 15 (11.1 %) 3 (5.6 %) 12 (15.2 %)  
 Left ventricular ejection fraction  (%) 57.2 ± 12.2 60.0 ± 12.8 57.4 ± 11.8 0.831
Medication on admission no. (%)
 ACE inhibitors 85 (63.0 %) 35 (63.6 %) 50 (62.5 %) 0.893
 Angiotensin receptor blockers 29 (21.5 %) 13 (23.6 %) 16 (20 %) 0.672
 Beta blockers 115 (85.2 %) 45 (81.8 %) 70 (87.5 %) 0.461
 Calcium channel blockers 28 (20.7 %) 17 (30.9 %) 11 (13.8 %) 0.019
 Diuretics 62 (45.9 %) 27 (49.1 %) 35 (43.8 %) 0.600
 Statins 109 (80.7 %) 45 (81.8 %) 64 (80 %) 0.828
 Nitrates 5 (3.7 %) 1 (1.8 %) 4 (5 %) 0.648
 Aspirin 115 (85.2 %) 47 (85.5 %) 58 (72.5 %) 0.093
Laboratory parameters
 Glucose mg/dL 126.4 ± 58.6 167.1 ± 72.3 99.0 ± 19.2 0.0001
 HbA1c (%) 6.4 ± 1.0 7.2 ± 1.2 5.9 ± 0.4 0.0001
 Serum creatinine mg/dL 0.98 ± 0.33 1.01 ± 0.33 0.97 ± 0.32 0.645
 Glomerular filtration rate mL/min 65.1 ± 11.0 64.3 ± 12.4 65.7 ± 9.9 0.463
 Triglycerides mg/dL 166.2 ± 204.5 199.4 ± 302.8 144.4 ± 84.2 0.137
 Cholesterol mg/dL 184.645 ± 48.8 173.2 ± 44.6 192.5 ± 50.2 0.023
 HDL cholesterol mg/dL 49.9 ± 17.7 45.2 ± 16.6 53.2 ± 17.8 0.009
 LDL cholesterol mg/dL 110.3 ± 37.3 102.0 ± 34.2 116.0 ± 38.4 0.030
 C-reactive protein mg/L 4.4 ± 6.5 4.5 ± 5.8 4.3 ± 7.0 0.826
 Leucocytes 109/L 7.3 ± 2.1 7.3 ± 1.7 7.2 ± 2.3 0.807
 Concentration of Annexin V + MP/µl 778.72 ± 1439.4 1144.0 ± 1849.4 526.2 ± 1009.1 0.014
  1. Continuous data are expressed as mean ± standard deviation and categorical data are expressed as frequencies. Chronic kidney disease was defined as a glomerular filtration rate <60 mL/min
  2. DM diabetes mellitus, NDM non diabetes mellitus, CAD coronary artery disease, MI myocardial infarction, ACE angiotensin-converting enzyme, LDL low-density lipoprotein, HDL high-density lipoprotein, MP microparticle
  3. Italic values indicate significance of p value (p < 0.05)