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Table 1 Baseline characteristics of the study population

From: Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

Characteristic

Total (n = 135)

DM (n = 55)

NDM (n = 80)

p value

Age in years

66.4 ± 10.9

67.6 ± 10.6

65.5 ± 11.1

0.279

Gender no. (%)

 

0.711

 Female

45 (33.3 %)

17 (30.9 %)

28 (35 %)

 

 Male

90 (66.7 %)

38 (69.1 %)

52 (65 %)

 

Cardiovascular risk factors no. (%)

 Arterial hypertension

110 (81.5 %)

50 (90.9 %)

60 (75 %)

0.024

 Hyperlipoproteinemia

71 (52.6 %)

29 (52.7 %)

42 (52.5 %)

0.979

 Family history of CAD

40 (29.6 %)

14 (25.5 %)

16 (20 %)

0.529

 Smoking

29 (21.5 %)

10 (18.2 %)

19 (23.8 %)

0.525

 Body mass index kg/m2

28.4 ± 5.2

30.5 ± 5.4

26.9 ± 4.5

0.001

Medical history no. (%)

 Previous MI (6 months)

40 (29.6 %)

16 (29.1 %)

24 (30 %)

0.910

 Previous bypass

15 (11.1 %)

8 (14.5 %)

7 (8.8 %)

0.404

 Previous stroke

7 (5.2 %)

3 (5.5 %)

4 (5 %)

0.907

 Chronic kidney disease

4 (3.0 %)

2 (3.6 %)

2 (2.5 %)

0.702

Coronary artery disease no. (%)

 

0.009

 3 vessels

49 (36.3 %)

24 (44.4 %)

25 (31.7 %)

 

 2 vessels

37 (27.4 %)

20 (37.0 %)

17 (21.5 %)

 

 1 vessel

15 (11.1 %)

3 (5.6 %)

12 (15.2 %)

 

 Left ventricular ejection fraction  (%)

57.2 ± 12.2

60.0 ± 12.8

57.4 ± 11.8

0.831

Medication on admission no. (%)

 ACE inhibitors

85 (63.0 %)

35 (63.6 %)

50 (62.5 %)

0.893

 Angiotensin receptor blockers

29 (21.5 %)

13 (23.6 %)

16 (20 %)

0.672

 Beta blockers

115 (85.2 %)

45 (81.8 %)

70 (87.5 %)

0.461

 Calcium channel blockers

28 (20.7 %)

17 (30.9 %)

11 (13.8 %)

0.019

 Diuretics

62 (45.9 %)

27 (49.1 %)

35 (43.8 %)

0.600

 Statins

109 (80.7 %)

45 (81.8 %)

64 (80 %)

0.828

 Nitrates

5 (3.7 %)

1 (1.8 %)

4 (5 %)

0.648

 Aspirin

115 (85.2 %)

47 (85.5 %)

58 (72.5 %)

0.093

Laboratory parameters

 Glucose mg/dL

126.4 ± 58.6

167.1 ± 72.3

99.0 ± 19.2

0.0001

 HbA1c (%)

6.4 ± 1.0

7.2 ± 1.2

5.9 ± 0.4

0.0001

 Serum creatinine mg/dL

0.98 ± 0.33

1.01 ± 0.33

0.97 ± 0.32

0.645

 Glomerular filtration rate mL/min

65.1 ± 11.0

64.3 ± 12.4

65.7 ± 9.9

0.463

 Triglycerides mg/dL

166.2 ± 204.5

199.4 ± 302.8

144.4 ± 84.2

0.137

 Cholesterol mg/dL

184.645 ± 48.8

173.2 ± 44.6

192.5 ± 50.2

0.023

 HDL cholesterol mg/dL

49.9 ± 17.7

45.2 ± 16.6

53.2 ± 17.8

0.009

 LDL cholesterol mg/dL

110.3 ± 37.3

102.0 ± 34.2

116.0 ± 38.4

0.030

 C-reactive protein mg/L

4.4 ± 6.5

4.5 ± 5.8

4.3 ± 7.0

0.826

 Leucocytes 109/L

7.3 ± 2.1

7.3 ± 1.7

7.2 ± 2.3

0.807

 Concentration of Annexin V + MP/µl

778.72 ± 1439.4

1144.0 ± 1849.4

526.2 ± 1009.1

0.014

  1. Continuous data are expressed as mean ± standard deviation and categorical data are expressed as frequencies. Chronic kidney disease was defined as a glomerular filtration rate <60 mL/min
  2. DM diabetes mellitus, NDM non diabetes mellitus, CAD coronary artery disease, MI myocardial infarction, ACE angiotensin-converting enzyme, LDL low-density lipoprotein, HDL high-density lipoprotein, MP microparticle
  3. Italic values indicate significance of p value (p < 0.05)